Inhibitors of HIV protease useful for the treatment of AIDS

Details Inhibitors of HIV protease useful for the treatment of AIDS Inhibitors of HIV protease useful for the treatment of AIDS

1992-12-22

1995-12-12

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564166, 568 63, C07C32128, C07C32320

Patent

active

054751365

ABSTRACT:
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.

REFERENCES:
patent: 5142056 (1992-08-01), Kempe et al.
Thomas Meck, "Human Immunodeficiency Virus1 . . . ", Proc. Natl. Acad. Sci, USA, vol. 86, pp. 1841-1845, Mar. 1989.
Karin Moelling, "In Vitro Inhibition of HIV-1 Proteinaseby Cerulenin," FEBS Letters, vol. 261, #2, pp. 373-377, Feb. 1990.
Jeffrey Blumenstein, "Synthetic Non-Peptide Inhibitors of HIV Protease", Biochem and Biophys Res Comm., vol. 163, #2, pp. 980-987, Sep. 1989.
Roberts, N. A. et al., Science, 248, 358-361 (1990).
Vara Prasad, J. V. N. et al., Peptides, Chemistry and Biology, Proceeding of the Twelfth American Peptide Symposium, Jun. 16-21, 721-722 (1991).
Thaisrivongs, S. et al., J. Med Chem, 34, 2344-2356 (1991).

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