Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-02-27
2007-02-27
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S377000, C514S461000, C548S125000, C548S196000, C549S473000
Reexamination Certificate
active
11271437
ABSTRACT:
Substituted aryl aminomethyl thiazole ureas and analogues thereof that act as inhibitors of viral capsid formation, including HIV capsid formation, are provided here. Generally the virus capsid formation inhibitors described herein are compounds of Formula Iwherein the variables A, R1, R2, R3, R4, X, Y, Z, A5, A6, A7, R8, R9, R12, and R13are defined herein. Pharmaceutical compositions comprising such compounds and methods of treating animals infected with a virus having a capsid protein are provided herein. Methods of using such compounds to treat human patients infected with an HIV virus and reducing the mortality of AIDS are also provided herein.
REFERENCES:
patent: 5162360 (1992-11-01), Creswell et al.
patent: 5424431 (1995-06-01), Ohta et al.
patent: 6649641 (2003-11-01), Behrens et al.
patent: 6762318 (2004-07-01), Kodra et al.
patent: 6881746 (2005-04-01), Lau et al.
patent: WO 2005/092865 (2005-10-01), None
Chaimbault, et al. “Synthesis, Antitumour and Anti-HIV Screening of Oxazolidines and Oxazolidinones Derivatives” Pharm. Pharmacol. Commun. 1999, vol. 5, pp. 211-215.
Chun Tang, et al., “Antiviral Inhibition of the HIV-1 Capsid Protein,” J. Mol. Biol. 32: 1013-1020 (2003).
Chaimbault, C. et al., “Synthesis, Antitumour and Anti-HIV Screening of Oxazolidines and Oxazolidinones Derivatives,”Pharm. Pharmacol. Commun. (1999) 5: 211-215.
Database Beilstein [online], Beilstein Institut Zur Foederung Der Chemischen Wissenschaften, DE; Database Accession No. 3008250, 3005712, 301178 (BRN) abstract & Gehlen, H. et al.: Journal Fuer Praktische Chemie, Wiley, Weinheim, DE, (1968) 38: 107-112.
International Search Report for International Application No. PCT/US2005/041358, mailed Jul. 6, 2006.
Agarwal Atul
Chen Xi
Deshpande Milind
Summers Michael F.
Cantor & Colburn LLP
Kosack Joseph R.
McKane Joseph K.
LandOfFree
Inhibitors of HIV-1 capsid formation: substituted aryl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of HIV-1 capsid formation: substituted aryl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of HIV-1 capsid formation: substituted aryl... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3823891