Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-03-18
2008-03-18
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S326000, C514S371000, C544S367000, C546S209000, C548S190000, C548S200000
Reexamination Certificate
active
11096550
ABSTRACT:
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
REFERENCES:
patent: 5925672 (1999-07-01), Piomelli et al.
patent: 0827742 (1998-03-01), None
Marks et al. “Histone Deacetylases and Cancer: Causes and Therapies”Nature Reviews: Cancer1:194-202 (2001).
Finnin et al. “Structures of a histone deacetylase homologue bound to the TSA and SAHA Inhibitors”Nature401:188-193 (1999).
Hamada et al. “An Improved Synthesis of Arylsulfonyl Chlorides from Aryl Halides”Synthesis-Communication852-854 (1986).
Huang et al. “Design, Synthesis and Structure-Activity Relationships of Benzoxazinone-Based Factor Xa Inhibitors”Biorg. Med. Chem. Lett. 13:561-566 (2003).
Morimoto et al. “Potent and Selective ET-A Antagonists. 2. Disclvery and Evaluation of Potent and Water Soluble N-(6-(2-(Aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide Derivatives”J. Med. Chem. 44:3369-3377.
Anandan Sampath K.
Patel Dinesh V.
Ward John
Xiao Xiao-Yi
Chu Yong
King & Spalding
McKane Joseph K.
Miikana Therapeutics
LandOfFree
Inhibitors of histone deacetylase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of histone deacetylase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of histone deacetylase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3913355