Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

2007-10-30

2007-10-30

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S461000, C514S465000, C514S342000, C514S362000, C514S363000, C514S365000, C546S279700, C546S281100, C546S281700, C546S282700, C548S125000, C548S146000

Reexamination Certificate

active

09817374

ABSTRACT:
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

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Cohen et al. Tetrahedron Letters, 22(35): 3377-3380, 1981.
See Rosato et al., Expert Opin. Investig. Drugs 13(1), 21-38, 2004.
Manfred Jung et al., Journal of Medicinal Chemistry, American Chemical Society, “Amide Analogues of Trichostatin A as Inhibitors of Histone Deacertylase and Inducers of Terminal Cell Differentiation”, 42:4669-4679, 1999.
Jung et al., Bioorganic & Medicinal Chemistry Letters, “Analogues of Trichostatin A and Trapoxin B as Histone Deacetylase Inhibitors”, 7:1655-1658.
Suzuki et al, Journal of Medicinal Chemistry, American Chemical Society, “Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives”, 42:3001-3003, 1999.

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