Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-07
2007-08-07
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S408000, C514S317000, C546S192000, C548S523000, C548S537000, C548S950000
Reexamination Certificate
active
11090713
ABSTRACT:
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
REFERENCES:
patent: 5366878 (1994-11-01), Pederson et al.
patent: 5635377 (1997-06-01), Pederson et al.
patent: 5652355 (1997-07-01), Metelev et al.
patent: 6174905 (2001-01-01), Suzuki et al.
patent: 6653309 (2003-11-01), Saunders et al.
patent: 6777217 (2004-08-01), Schreiber et al.
patent: 2003/0096844 (2003-05-01), Kozlowski et al.
patent: 2003/0232859 (2003-12-01), Kozlowski et al.
patent: 2004/0010013 (2004-01-01), Friary et al.
patent: 2004/0044051 (2004-03-01), Kozlowski et al.
patent: 2004/0106599 (2004-06-01), Delorme et al.
patent: 2004/0132804 (2004-07-01), Tong et al.
patent: 2004/0147569 (2004-07-01), Suzuki et al.
patent: 2004/0186148 (2004-09-01), Shankar et al.
patent: 2005/0096222 (2005-05-01), Hidaka et al.
patent: 2480356 (2003-10-01), None
patent: 2484065 (2003-11-01), None
patent: 2490579 (2004-01-01), None
patent: 0 847 992 (1998-06-01), None
patent: 258863/96 (1996-09-01), None
patent: 11269146 (1999-10-01), None
patent: 2003221380 (2003-08-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 01/70675 (2001-09-01), None
patent: WO 03/024448 (2003-03-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 2004/058234 (2004-07-01), None
patent: WO 2004/069133 (2004-08-01), None
patent: WO 2004/069823 (2004-08-01), None
patent: WO 2004/071400 (2004-08-01), None
Csordas, Adam., “On the Biological Role of Histone Acetylation,”Biochem. J., vol. 265 (1990) pp. 23-38.
Taunton, Jack, et al. “A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p,”Science, vol. 272 (1996) pp. 408-411.
Grozinger, Christina M., et al., “Three Proteins Define a Class of Human Histone Deacetylases Related to Yeast Hdalp,”PNAS, vol. 96 (1999) pp. 4868-4873.
Kao, Hung-Ying, et al., “Isolation of a Novel Histone Deacetylase Reveals that Class I and Class II Deacetylases Promote SMRT-Mediated Repression,”Genes&Development, vol. 14 (2000) pp. 55-66.
Van den Wyngaert, Ilse, et al. “Cloning and Characterization of Human Histone Deacetylase 8,”FEBS Letters, vol. 478 (2000) pp. 77-83.
Zhou, Xianbo, et al., “Cloning and Characterization of a Histone Deacetylase, HDAC9,”PNAS, vol. 98, No. 19, (2001) pp. 10572-10577.
Kao, Hung-Ying, et al., “Isolation and Characterization of Mammalian HDAC10, a Novel Histone Deacetylase,”J. Biol. Chem., vol. 277, No. 1, (2002) pp. 187-193.
Gao, Lin, et al. “Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family,”J. Biol. Chem., vol. 277, No. 28 (2002) pp. 25748-25755.
Richon, Victoria M., et al. “A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases,”PNAS, vol. 95 (1998) pp. 3003-3007.
Yoshida, Minoru & Beppu, Teruhiko, “Reversible Arrest of Proliferation of Rat 3Y1 Fibroblasts in Both the G1 and G2 Phases by Trichostatin A,”Experimental Cell Research, vol. 177 (1988) pp. 122-131.
Finnin, Michael S., et al., “Structures of a Histone Deacetylase Homologue Bound to the TSA and SAHA Inhibitors,”Nature, vol. 401 (1999) pp. 188-193.
Yoshida, Minoru, et al., “Potent and Specific Inhibition of Mammalian Histone Deacetylase BothIn VivoandIn Vitroby Trichostatin A,”J. Biol. Chem., vol. 265, No. 28 (1990) pp. 17174-17179.
Ramchandani, Shyam, et al., “Inhibition of Tumorigenesis by a Cytosine-DNA, Methyltransferase, Antisense Oligodeoxynucleotide,”PNAS, vol. 94 (1997) pp. 684-689.
Pon, Richard T., “Solid Phase Supports for Oligonucleotide Synthesis,”Methods in Molecular Biology, vol. 20 (1993) pp. 465-496.
Alaimo, Robert J., “The Preparation and Characterization of 2-Amino-5,6-Dichloro and 2-Amino-6,7-Dichlorobenzothiazole,”J. Het. Chem., vol. 8 (1971) pp. 309-310.
Zee-Cheng, Robert K. Y. & Cheng, C. C., “Antileukemic Activity of Substituted Ureidothiazoles, Ureidothiadiazoles, and Related Compounds,”J. Med. Chem., vol. 22, No. 1 (1979) pp. 28-32.
Taurins, Alfred & Blaga, Aurel, “Synthesis of Pyridyl- and Quinolyl-Substituted 2-Aminothiazoles,”J. Het. Chem., vol. 7 (1970) pp. 1137-1141.
Rosowsky, Andre, et al., “5-Deaza-7-Desmethylene Analogues of 5,10-Methylene-5,6,7,8-Tetrahydrofolic Acid and Related Compounds: Synthesis andIn VitroBiological Activity,”J. Het. Chem., vol. 31 (1994) pp. 1241-1250.
Meyer, Thomas, et al., “A Derivative of Staurosporine (CGP 41 251) Shows Selectivity for Protein Kinase C Inhibition andIn VitroAnti-Proliferative as Well asIn VivoAnti-Tumor Activity,”Int. J. Cancer, vol. 43 (1989) pp. 851-856.
Anderson, Malcolm, et al., “Imidazo[1,2-a]pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation,”Bioorganic&Medical Chemistry Letters, vol. 13 (2003) pp. 3021-3026.
Zlatoidsk{dot over (y)}, P. & Maliar T., “Synthesis of 4-(4-Guanidinobenzoyloxy)Benzamides and 1 -(4-Guanidinobenzoyloxy)Benzoyloxy Acetamides as Trypsin Inhibitors,”Eur. J. Med. Chem., vol. 31 (1996) pp. 895-899.
Zimmermann, Jürg, et al., “Phenylamino-Pyrimidine (PAP)—Derivates: A New Class of Potent and Highly Selective PDGF—Receptor Autophosphorylation Inhibitors,”Bioorganic&Medicinal Chemistry Letters, vol. 6, No. 11 (1996) pp. 1221-1226.
Barvian, Mark, et al., “Pyrido[2,3-d]Pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases,”J. Med. Chem., vol. 43 (2001), p. 1016.
Barvian, Mark, et al., “Pyrido[2,3-d]Pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases,”J. Med. Chem., vol. 43, No. 24 (2000) pp. 4606-4616.
Suzuki, Tsuneji, et al, “Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives,”J. Med. Chem., vol. 42 (1999) pp. 3001-3003.
Piper, James R. et al., “Analogues of Methotrexate in Rheumatoid Arthritis. 2. Effects of 5-Deazaaminopterin, 5,10-Dideazaaminopterin, and Analogues on Type II Collagen-Induced Arthritis in Mice,”J. Med. Chem., vol. 40, No. 3 (1997) pp. 377-381.
Grell, Wolfgang, et al., “Repaglinide and Related Hypoglycemic Benzoic Acid Derivatives,”J. Med. Chem, vol. 41 (1998) pp. 5219-2546.
Geoffroy, Otto J. et al., “Chemoselective One-Pot Reductive Deamination of Aryl Amines,”Tetrahedron Letters, vol. 42 (2001) pp. 5367-5369.
Boger, Dale L. et al., “Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity,”J. Am. Chem. Soc., vol. 122 (2000) pp. 6382-6394.
Matsuoka, Hiroharu, et al., “Antirheumatic Agents: Novel Methotrexate Derivatives Bearing a Benzoxazine or Benzothiazine Moiety,”J. Med. Chem., vol. 40 (1997) pp. 105-111.
Hennequin, Laurent F., et al., “Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors,”J. Med. Chem., vol. 45 (2002) pp. 1300-1312.
Taylor, Edward C., “Novel 5-Desmethylene Analogues of 5,10-Dideaza-5,6,7,8-Tetrahydrofolic Acid as Potential Anticancer Agents,”J. Org. Chem., vol. 57 (1992) pp. 3218-3225.
Zhu, Zhijian, et al., “Synthesis of 2,6,7-Trichloro-1-(β-D-Ribofuranosyl)Naphtho[2,3-d]Imidazole: A Linear Dimensional Analogue of the Antiviral Agent TCRB,”J. Org. Chem., vol. 63 (1998) pp. 977-983.
Bouchain Giliane
Delorme Daniel
Frechette Sylvie
Gaudette Frederic
Isakovic Ljubomir
Chu Yong
McDonnell Boehnen & Hulbert & Berghoff LLP
MethylGene Inc.
Saeed Kamal A.
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