Inhibitors of histone deacetylase

Organic compounds -- part of the class 532-570 series – Organic compounds – Persulfonate esters

Reissue Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S001000, C560S004000, C560S019000, C560S024000, C560S319000

Reissue Patent

active

10880444

ABSTRACT:
The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

REFERENCES:
patent: 2279560 (1942-04-01), Dietrich
patent: 2279973 (1942-04-01), Dietrich
patent: 4013768 (1977-03-01), Fauran et al.
patent: 4035376 (1977-07-01), Janssen et al.
patent: 4173577 (1979-11-01), Sallmann et al.
patent: 4792560 (1988-12-01), Huang
patent: 4977188 (1990-12-01), Kneen et al.
patent: 5028629 (1991-07-01), Hite et al.
patent: 5218124 (1993-06-01), Failli et al.
patent: 5364944 (1994-11-01), Failli et al.
patent: 5700811 (1997-12-01), Breslow et al.
patent: 5773647 (1998-06-01), Leone-Bay et al.
patent: 5776888 (1998-07-01), Leone-Bay et al.
patent: 5929097 (1999-07-01), Levin et al.
patent: 6090958 (2000-07-01), Leone-Bay et al.
patent: 6653309 (2003-11-01), Saunders et al.
patent: 2003/0232859 (2003-12-01), Kozlowski et al.
patent: 0196674 (1986-10-01), None
patent: 0519831 (1992-06-01), None
patent: 0737671 (1996-10-01), None
patent: 0827742 (1998-03-01), None
patent: 0847992 (1998-06-01), None
patent: 0023986.3 (2000-09-01), None
patent: A-56-0511441 (1981-05-01), None
patent: 11-302173 (1999-11-01), None
patent: WO 90/01929 (1990-03-01), None
patent: WO 93/12075 (1993-06-01), None
patent: WO93/12075 (1993-06-01), None
patent: WO 95/13264 (1995-05-01), None
patent: WO-A-9506554 (1995-09-01), None
patent: WO 96/30036 (1996-10-01), None
patent: WO 97/11366 (1997-03-01), None
patent: WO 97/36480 (1997-10-01), None
patent: WO 97/43249 (1997-11-01), None
patent: WO 98/16503 (1998-04-01), None
patent: WO 98/34632 (1998-08-01), None
patent: WO98/38859 (1998-11-01), None
patent: WO-98/55449 (1998-12-01), None
patent: WO 99/31052 (1999-06-01), None
patent: WO00/56704 (2000-09-01), None
patent: WO00/69819 (2000-11-01), None
patent: WO-A-0222577 (2002-03-01), None
patent: WO 02/30879 (2002-04-01), None
Allais et al., “Derives de las serie des acides benzoylphenylacetiques anti-imflammatories et analgesiques”, Eur. J. Med. Chem., 9(4):381-389 (1974).
Atsushi et al., Japanese Patent Office—Patent Abstracts of Japan, Pub. No. 07287412 A, Oct. 31, 1995.
Coker et al., “A Treatise on Photo-Elasticity” Cambridge at the University Press, 215-220 (1993).
Csordas, “On the Biological Role of Histone Acetylation” Biochem, J. 1990, vol. 265, pp 23-38.
Finnin et al., “Structures of a Histone Deacetylase Homologue Bound to the TSA and SAHA Inhibitors” Letters to Nature, 1999, vol. 401, pp 188-193.
Grozinger et al., “Three Proteins Define a Class of Human Histone Deacetylases Related to Yeast Hda 1p” Proc. Natl. Acad. Sci USA, 96, 1993, pp 4868-4873.
Janssen, “Suprofen (R 25 061), a New Potent Inhibitor of Prostaglandin Biosynthesis” Arzneim.-Porsch. (Drug Res.) 1975, 25, Nr. 10.
Jung et al., “Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation” J. Med. Chem., 1999, vol. 42, pp. 4669-4679.
Kao et al., “Isolation of a Novel Histone Deacetylase Reveals That Class I and Class II Deacetylases Promote SMRT-Mediated Repression” Genes & Development, 2000, vol. 14, pp 55-66.
Kim et al., “Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase” Oncogene, 1999, vol. 18, pp. 2461-2470.
Makoto et al., Japanese Patent Office—Patent Abstracts of Japan, Pub. No. 59112963 A, Jun. 29, 1984.
Ohtani et al., “(2E)-5-[3-[(Phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamic Acid and its Derivatives as Novel and Potent Inhibitors of ras Transformation” J Med Chem., 1996, vol. 39, No. 15, pp 2871-2873.
Richon et al., “A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases” Proc. Natl. Acad Sci, 1998, vol. 95, pp 3003-3007.
Richon et al., “Second generation hybird polar compounds are potent inducers of transformed cell differentiation” Proc. Natl. Acad. Sci. U S A., 1996, vol. 93, No. 12, pp. 5705-5708.
Rovnyak et al., “Synthesis and Antiinflammatory Activities of ( α-Cyclopropl-p-tolyl)acetic Acid and Related Compounds” J Med Chem., 1973, vol. 16, No. 5, pp 487-490.
Saito et al., “A Synthetic Inhibitor of Histone Deacetylase, MS-27-275, with Marked in Vivo Antitumor Activity Against Human Tumors” Proc Natl Acad Sci U S A., 1999, vol. 96, No. 8, pp 4592-4597.
Sanchez del Pino et al., “Properties of the Yeast Nuclear Histone Deacetylase” Biochem J., 1994, vol. 303 ( Pt 3), pp 723-729.
Sonoda et al., “Oxamflatin: a novel compound which reverses malignant phenotype to normal one via induction of JunD” Oncogene, 1996, vol. 13, No. 1, pp 143-149.
Summers JB et al., “Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships” J Med Chem., 1990, vol. 33, No. 3, pp. 992-998.
Suzuki et al., “Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives” J Med Chem., 1999, vol. 42, No. 15, pp 3001-3003.
Taunton et al., “A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p” Science, 1996, vol. 272, pp 408-411.
Toyoki et al., Japanese Patent Office—Patent Abstracts of Japan, Pub. No. 10287634 A, Oct. 27, 1998.
Tsuji et al., “A new antifungal antibiotic, trichostatin” J Antibiot (Tokyo)., 1976, vol. 29, No. 1, pp 1-6.
Tsuneshi et al., Japanese Patent Office—Patent Abstracts of Japan, Pub. No. 10162583 A, Jul. 7, 1998.
Wyngaert et al., “Cloning and Characterization of Human Histone Deacetylase 8” FRBS, 2000, vol. 478, pp 77-83.
Yoshida et al., “Potent and Specific Inhibition of Mammalian Histone Deacetylase Both in Vivo and in Vitro by Trichostatin A” J Biol Chem., 1990, vol. 265, No. 28, pp 17174-17179.
Yoshida et al., “Effects of Trichostatins on Differentiation of Murine Eryothroleukemia Cells” Cancer Res., 1987, vol. 47, No. 14, pp 3688-3691.
Yoshida et al., “Reversible Arrest of Proliferation of Rat 3Y1 Fibroblasts in Both the G1 and G2 Phases by Trichostatin A” 1988, vol. 177, pp 122-131.
Database Beilstein; Beilstein Informationssysteme GmbH; XP002162157.
Database Beilstein; Beilstein Informationssysteme GmbH; XP002162158.
Database Beilstein; Beilstein Informationssysteme GmbH; XP002162159.
Database Beilstein; Beilstein Informationssysteme GmbH; XP002162160.
Database Beilstein; Beilstein Informationssysteme GmbH; XP002162161.
Hideo K. et al., “Substituted Acetohydroxamic Derivatives”, Chem. Ab., 91(13):Abstract No. 107818 (1979).
Kim, Y.B. et al., “Oxamflatin is a Novel Antitumor Compounds that Inhibits Mammalian Histone Deacetylase”, Chemical Abstracts, 181(8):Abstract No. 97120 (1999).
Glick, R.D. et al., “Hybrid Polar Histon Deacetylase Inhibitor Induces Apoptosis and CD95/CD95 Ligand Expression in Human Neuroblastoma”, Chem. Ab., 131(24): Abstract No. 317417 (1999).
Hikaru, Sonoda et al., “Oxamflatin: A Novel Compound Which Reverses Malignant Phenotype to Normal One Via Induction of JunD”, Oncogene, 13:143-149.
Young, Bae Kim et al., “Oxamflatin is a Novel Antitumor Compound that Inhibits Mammalian Histone Deacetylase”, Oncogene, 18:2461-2470.
Mitsuake, Ohtani et al., Journal of Medicinal Chemistry, 39(15):2871-2873.
Tsuneji, Suzuki et al., “Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives”, Journal of Medicinal Chemistry, 42(15):3001-3003 (1999).
Manfred, Jung et al., “Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation”, J. Med. Chem., 42:4669-4679 (1999).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of histone deacetylase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of histone deacetylase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of histone deacetylase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3731219

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.