Inhibitors of histone deacetylase

Details Inhibitors of histone deacetylase Inhibitors of histone deacetylase

2008-03-18

2008-03-18

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S326000, C514S371000, C544S367000, C546S209000, C548S190000, C548S200000

Reexamination Certificate

active

07345043

ABSTRACT:
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.

REFERENCES:
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Marks et al. “Histone Deacetylases and Cancer: Causes and Therapies”Nature Reviews: Cancer1:194-202 (2001).
Finnin et al. “Structures of a histone deacetylase homologue bound to the TSA and SAHA Inhibitors”Nature401:188-193 (1999).
Hamada et al. “An Improved Synthesis of Arylsulfonyl Chlorides from Aryl Halides”Synthesis-Communication852-854 (1986).
Huang et al. “Design, Synthesis and Structure-Activity Relationships of Benzoxazinone-Based Factor Xa Inhibitors”Biorg. Med. Chem. Lett. 13:561-566 (2003).
Morimoto et al. “Potent and Selective ET-A Antagonists. 2. Disclvery and Evaluation of Potent and Water Soluble N-(6-(2-(Aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide Derivatives”J. Med. Chem. 44:3369-3377.

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