Inhibitors of histone deacetylase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S242000

Reexamination Certificate

active

07816363

ABSTRACT:
This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

REFERENCES:
patent: 2005/0096468 (2005-05-01), Van Emelen et al.
patent: 0188094 (1985-12-01), None
patent: 0827742 (1998-03-01), None
patent: WO 98/55449 (1998-12-01), None
patent: WO 00/52001 (2000-09-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 01/70875 (2001-09-01), None
patent: WO 03/011851 (2003-02-01), None
Finnin et al., “Structures of histone deacetylase homologue bound to the TSA and SAHA inhibitors,”Nature, 1999, pp. 188-193, vol. 401.
PCT International Search Report mailed Aug. 13, 2003 for PCT Application No. PCT/EP03/02514 which relates to U.S. Patent Application filed herewith.

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