Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-03-15
2010-11-23
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S617000, C514S241000, C514S252010, C514S252100, C514S256000, C514S269000, C514S277000, C514S359000, C544S196000, C544S264000, C544S283000, C544S353000, C546S268100, C564S155000, C564S161000
Reexamination Certificate
active
07838520
ABSTRACT:
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
REFERENCES:
patent: 2754286 (1956-07-01), Martin
patent: 3208990 (1965-09-01), Benz et al.
patent: 3576869 (1971-04-01), Schellenbaum
patent: 4994479 (1991-02-01), Mase et al.
patent: 5137918 (1992-08-01), Weiershausen et al.
patent: 5332750 (1994-07-01), Mederski et al.
patent: 5366878 (1994-11-01), Pederson et al.
patent: 5635377 (1997-06-01), Pederson et al.
patent: 5652355 (1997-07-01), Metelev et al.
patent: 5945450 (1999-08-01), Takenouchi et al.
patent: 6034251 (2000-03-01), Aslanian et al.
patent: 6174905 (2001-01-01), Suzuki et al.
patent: 6180844 (2001-01-01), Fujita et al.
patent: 6376515 (2002-04-01), Zhu et al.
patent: 6541661 (2003-04-01), Delorme et al.
patent: 6632815 (2003-10-01), Zhu et al.
patent: 6653309 (2003-11-01), Saunders et al.
patent: 6777217 (2004-08-01), Schreiber et al.
patent: 6897220 (2005-05-01), Delorme et al.
patent: 7253204 (2007-08-01), Delorme et al.
patent: 7282608 (2007-10-01), Raeppel et al.
patent: 7595343 (2009-09-01), Delorme et al.
patent: 2002/0061860 (2002-05-01), Li et al.
patent: 2003/0096844 (2003-05-01), Kozlowski et al.
patent: 2003/0232859 (2003-12-01), Kozlowski et al.
patent: 2004/0010013 (2004-01-01), Friary et al.
patent: 2004/0044051 (2004-03-01), Kozlowski et al.
patent: 2004/0087798 (2004-05-01), Yamada
patent: 2004/0106599 (2004-06-01), Delorme et al.
patent: 2004/0132804 (2004-07-01), Tong et al.
patent: 2004/0147569 (2004-07-01), Suzuki et al.
patent: 2004/0186148 (2004-09-01), Shankar et al.
patent: 2005/0096222 (2005-05-01), Hidaka et al.
patent: 2005/0288282 (2005-12-01), Delorme et al.
patent: 2006/0058298 (2006-03-01), Delorme et al.
patent: 2006/0063210 (2006-03-01), Li et al.
patent: 2007/0213330 (2007-09-01), Delorme et al.
patent: 2008/0132503 (2008-06-01), Moradei et al.
patent: 2136288 (1994-11-01), None
patent: 2480356 (2003-10-01), None
patent: 2484065 (2003-11-01), None
patent: 2490579 (2004-01-01), None
patent: 2615105 (2007-01-01), None
patent: 14 70 097 (1969-06-01), None
patent: 0 657 454 (1994-11-01), None
patent: 0 847 992 (1998-06-01), None
patent: 1 256 341 (2002-11-01), None
patent: 96/258863 (1996-10-01), None
patent: 1999-269146 (1999-10-01), None
patent: 11269146 (1999-10-01), None
patent: 11-302173 (1999-11-01), None
patent: 1999-302173 (1999-11-01), None
patent: 2000-256194 (2000-09-01), None
patent: 2001131130 (2001-05-01), None
patent: 2002-332267 (2002-11-01), None
patent: 2003-137866 (2003-05-01), None
patent: 2003221380 (2003-08-01), None
patent: 98/42672 (1998-10-01), None
patent: 98/45252 (1998-10-01), None
patent: 00/03704 (2000-01-01), None
patent: 00/71703 (2000-11-01), None
patent: 01/16106 (2001-03-01), None
patent: 01/38322 (2001-05-01), None
patent: 01/60354 (2001-08-01), None
patent: 01/64643 (2001-09-01), None
patent: 01/68585 (2001-09-01), None
patent: 01/70675 (2001-09-01), None
patent: 02/069947 (2002-09-01), None
patent: 03/24448 (2003-03-01), None
patent: 03/075929 (2003-09-01), None
patent: 03/076395 (2003-09-01), None
patent: 03/076400 (2003-09-01), None
patent: 03/076401 (2003-09-01), None
patent: 03/076421 (2003-09-01), None
patent: 03/076422 (2003-09-01), None
patent: 03/076430 (2003-09-01), None
patent: 03/076438 (2003-09-01), None
patent: WO 03/087057 (2003-10-01), None
patent: 03/092686 (2003-11-01), None
patent: 2004/035525 (2004-04-01), None
patent: WO 2004/058234 (2004-07-01), None
patent: 04/069133 (2004-08-01), None
patent: 04/069823 (2004-08-01), None
patent: WO 2004/071400 (2004-08-01), None
patent: 05/030705 (2005-04-01), None
patent: 05/092899 (2005-10-01), None
patent: 06/122319 (2006-11-01), None
patent: 07/118137 (2007-10-01), None
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
Ragione et al., FEBS Letters 499. 199-204,2001.
Turner et al., Current Pharmaceutical Design. 2, 209-224, 1996.
Sugar et al., Diagn. Microbiol. Infect. Dis. 21: 129-133, 1995.
Snyder et al., J. Med. Liban 48(4): 208-214, 2000.
Suzuki et al., JP 2000256194; CA 133: 247304, 2000.
Suzuki et al., JP 11302173; CA 131: 319669, 1999.
Suzuki et al., JP 11269146; CA 131: 257321, 1999.
Csordas, Adam., “On the Biological Role of Histone Acetylation,” Biochem. J., vol. 265 (1990) pp. 23-38.
Taunton, Jack, et al. “A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p,” Science, vol. 272 (1996) pp. 408-411.
Grozinger, Christina M., et al., “Three Proteins Define a Class of Human Histone Deacetylases Related to Yeast Hda1p,” PNAS, vol. 96 (1999) pp. 4868-4873.
Kao, Hung-Ying, et al., “Isolation of a Novel Histone Deacetylase Reveals that Class I and Class II Deacetylases Promote SMRT-Mediated Repression,” Genes & Development, vol. 14 (2000) pp. 55-66.
Van den Wyngaert, Ilse, et al. “Cloning and Characterization of Human Histone Deacetylase 8,” FEBS Letters, vol. 478 (2000) pp. 77-83.
Zhou, Xianbo, et al., “Cloning and Characterization of a Histone Deacetylase, HDAC9,” PNAS, vol. 98, No. 19, (2001) pp. 10572-10577.
Kao, Hung-Ying, et al., “Isolation and Characterization of Mammalian HDAC10, a Novel Histone Deacetylase,” J. Biol. Chem., vol. 277, No. 1 (2002) pp. 187-193.
Gao, Lin, et al. “Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family,” J. Biol. Chem., vol. 277, No. 28 (2002) pp. 25748-25755.
Richon, Victoria M., et al. “A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases,” PNAS, vol. 95 (1998) pp. 3003-3007.
Yoshida, Minoru & Beppu, Teruhiko, “Reversible Arrest of Proliferation of Rat 3Y1 Fibroblasts in Both the G1 and G2 Phases by Trichostatin A,” Experimental Cell Research, vol. 177 (1988) pp. 122-131.
Finnin, Michael S., et al., “Structures of a Histone Deacetylase Homologue Bound to the TSA and SAHA Inhibitors,” Nature, vol. 401 (1999) pp. 188-193.
Yoshida, Minoru, et al., “Potent and Specific Inhibition of Mammalian Histone Deacetylase Both In Vivo and In Vitro by Trichostatin A,” J. Biol. Chem., vol. 265, No. 28 (1990) pp. 17174-17179.
Ramchandani, Shyam, et al., “Inhibition of Tumorigenesis by a Cytosine-DNA, Methyltransferase, Antisense Oligodeoxynucleotide,” PNAS, vol. 94 (1997) pp. 684-689.
Pon, Richard T., “Solid Phase Supports for Oligonucleotide Synthesis,” Methods in Molecular Biology, vol. 20 (1993) pp. 465-496.
Alaimo, Robert J., “The Preparation and Characterization of 2-Amino-5,6-Dichloro and 2-Amino-6,7-Dichlorobenzothiazole,” J. Het. Chem., vol. 8 (1971) pp. 309-310.
Zee-Cheng, Robert K. Y. & Cheng, C. C., “Antileukemic Activity of Substituted Ureidothiazoles, Ureidothiadiazoles, and Related Compounds,” J. Med. Chem., vol. 22, No. 1 (1979) pp. 28-32.
Taurins, Alfred & Blaga, Aurel, “Synthesis of Pyridyl- and Quinolyl-Substituted 2-Aminothiazoles,” J. Het. Chem., vol. 7 (1970) pp. 1137-1141.
Rosowsky, Andre, et al., “5-Deaza-7-Desmethylene Analogues of 5,10-Methylene-5,6,7,8-Tetrahydrofolic Acid and Related Compounds: Synthesis and In Vitro Biological Activity,” J. Het Chem., vol. 31 (1994) pp. 1241-1250.
Meyer, Thomas, et al., “A Derivative of Staurosporine (CGP 41 251) Shows Selectivity for Protein Kinase C Inhibition and In Vitro Anti-Proliferative as Well as In Vivo Anti-Tumor Activity,” Int. J. Cancer, vol. 43 (1989) pp. 851-856.
Anderson, Malcolm, et al., “Imidazo[1,2-a]pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation,” Bioorganic & Medical Chemistry Letters, vol. 13 (2003) pp. 3021-3026.
Zlatoidský, P. & Maliar T., &#x
Bouchain Giliane
Delorme Daniel
Frechette Sylvie
Leit Silvana
Moradei Oscar
Balasubramanian Venkataraman
McDonnell Boehnen & Hulbert & Berghoff LLP
MethylGene Inc.
LandOfFree
Inhibitors of histone deacetylase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of histone deacetylase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of histone deacetylase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4188393