Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-03-11
2009-11-10
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S275000, C544S295000, C544S323000, C544S332000
Reexamination Certificate
active
07615553
ABSTRACT:
This invention comprises the novel compounds of formula (I) wherein n, R1, R2, R3, R4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
REFERENCES:
patent: 3331843 (1967-07-01), Tomcufcik et al.
patent: 0 827 742 (1998-03-01), None
patent: 901749 (1962-07-01), None
patent: WO 98/55449 (1998-12-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 01/70675 (2001-09-01), None
Yokoyama et al., CAPLUS Abstract 105:226622 (1986).
Yokoyama et al., CAPLUS Abstract 105:208919 (1986).
Taylor et al., CAPLUS Abstract 55:33107 (1961).
Simone, Oncology: Introduction, Cecil Texbook of Medicine, 20th Edition, vol. 1, pp. 1004-1010, 1996.
Glaser, HDAC inhibitors: Clinical updates and mechanism-based potential, Biochemical Pharmacology (2007), doi:10.1016/j.bcp.2007.04.007.
Foks, H, et al ‘Investigations on Pyrazine Derivatives’ Dissert. Pharm. Pharmacol. vol. 24 (1972), pp. 577-583.
Foks, H. et al ‘Studies on Pyrazine Derivatives’ Pol. J. Pharmacol. Pharm. vol. 30 (1978) pp. 105-111.
Khuthier, A-H. et al ‘Studies of Tertiary Amine Oxides. 9. Thermal Rearrangement of 1-(4-Substituted-phenyl)piperidine N-Oxides to the Corresponding N-Hydroxylamines’ J. Org. Chem. vol. 52 (1987) pp. 1710-1713.
Walsh, D.A. et al ‘Synthesis and Antiallergy Activity of N-[2-(Dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide Derivatives’ J. Med. Chem. vol. 33 (1990) pp. 2028-2032.
Marks et al., “Histone Deacetylases and Cancer: Causes and Therapies”, Reviews: Cancer 1: 194-202, 2001.
Finnin et al., “Structures of a histone deacetlylase homologue bound to the TSA and SAHA inhibitors”, Nature, 401: 188-193, 1999.
Mosman, Tim, “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicty Assay”, Journal of Immunological Methods 65: 55-63, 1983.
Gorrod et al.. “ The Matabolism of N Ethyl N methylaniline by rabbit liver microsomes: The Measurement of metalbolites by gas liquid chromatography”, Xenobiotica 5: 453-462, 1975.
International Search Report PCT/EP03/02515 dated Aug. 18, 2003.
Angibaud Patrick Rene
Dyatkin Alexey Borisovich
Meerpoel Lieven
Van Brandt Sven Franciscus Anna
Van Emelen Kristof
Janssen Pharmaceutica N.V.
Rao Deepak
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