Inhibitors of histone deacetylase

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C564S176000, C514S395000, C514S438000, C514S613000, C514S620000, C544S379000, C544S369000, C544S359000, C544S295000, C546S213000, C548S304400, C549S077000

Reexamination Certificate

active

07868205

ABSTRACT:
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

REFERENCES:
patent: 3576869 (1971-04-01), Schellenbaum et al.
patent: 5137918 (1992-08-01), Weisershausen et al.
patent: 5332750 (1994-07-01), Mederski et al.
patent: 5366878 (1994-11-01), Pederson et al.
patent: 5635377 (1997-06-01), Pederson et al.
patent: 5652355 (1997-07-01), Metelev et al.
patent: 5945450 (1999-08-01), Takenouchi et al.
patent: 6034251 (2000-03-01), Aslanian et al.
patent: 6174905 (2001-01-01), Suzuki et al.
patent: 6376515 (2002-04-01), Zhu et al.
patent: 6541661 (2003-04-01), Delorme et al.
patent: 6632815 (2003-10-01), Zhu et al.
patent: 6653309 (2003-11-01), Saunders et al.
patent: 6777217 (2004-08-01), Schreiber et al.
patent: 6897220 (2005-05-01), Delorme et al.
patent: 7253204 (2007-08-01), Delorme et al.
patent: 7282608 (2007-10-01), Raeppel et al.
patent: 2002/0061860 (2002-05-01), Li et al.
patent: 2003/0096844 (2003-05-01), Kozlowski et al.
patent: 2003/0232859 (2003-12-01), Kozlowski et al.
patent: 2004/0010013 (2004-01-01), Friary et al.
patent: 2004/0044051 (2004-03-01), Kozlowski et al.
patent: 2004/0087798 (2004-05-01), Yamada
patent: 2004/0106599 (2004-06-01), Delorme et al.
patent: 2004/0132804 (2004-07-01), Tong et al.
patent: 2004/0147569 (2004-07-01), Suzuki et al.
patent: 2004/0186148 (2004-09-01), Shankar et al.
patent: 2005/0096222 (2005-05-01), Hidaka et al.
patent: 2005/0288282 (2005-12-01), Delorme et al.
patent: 2006/0058298 (2006-03-01), Delorme et al.
patent: 2007/0213330 (2007-09-01), Delorme et al.
patent: 2008/0132503 (2008-06-01), Moradei et al.
patent: 2136288 (1994-11-01), None
patent: 2480356 (2003-10-01), None
patent: 2484065 (2003-11-01), None
patent: 2490579 (2004-01-01), None
patent: 14 70 097 (1969-06-01), None
patent: 0 657 454 (1994-11-01), None
patent: 0 847 992 (1997-09-01), None
patent: 0 847 992 (1998-06-01), None
patent: 1 256 341 (2002-11-01), None
patent: 1996-258863 (1996-09-01), None
patent: 1999-269146 (1999-10-01), None
patent: 11269146 (1999-10-01), None
patent: 11269146 (1999-10-01), None
patent: 1999-302173 (1999-11-01), None
patent: 2001131130 (2001-05-01), None
patent: 2003-137866 (2003-05-01), None
patent: 2003221380 (2003-08-01), None
patent: 98/42672 (1998-10-01), None
patent: WO 98/45252 (1998-10-01), None
patent: WO 00/03704 (2000-01-01), None
patent: WO 01/16106 (2001-03-01), None
patent: WO 01/16106 (2001-03-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 01/60354 (2001-08-01), None
patent: WO 01/64643 (2001-09-01), None
patent: WO 01/68585 (2001-09-01), None
patent: WO 01/70675 (2001-09-01), None
patent: WO 02/069947 (2002-09-01), None
patent: WO 03/024448 (2003-03-01), None
patent: WO 03/024448 (2003-03-01), None
patent: WO 03/075929 (2003-09-01), None
patent: WO 03/076395 (2003-09-01), None
patent: WO 03/076400 (2003-09-01), None
patent: WO 03/076401 (2003-09-01), None
patent: WO 03/076421 (2003-09-01), None
patent: WO 03/076422 (2003-09-01), None
patent: WO 03/076430 (2003-09-01), None
patent: WO 03/076438 (2003-09-01), None
patent: WO 03/087057 (2003-10-01), None
patent: WO 03/092686 (2003-11-01), None
patent: WO 2004/058234 (2004-07-01), None
patent: WO 2004/069133 (2004-08-01), None
patent: WO 2004/069823 (2004-08-01), None
patent: WO 2004/071400 (2004-08-01), None
patent: 2005/030705 (2005-04-01), None
patent: 2005/092899 (2005-10-01), None
patent: 2006/122319 (2006-11-01), None
patent: 2007/118137 (2007-10-01), None
Valentino J. Stella et al.: “Prodrugs: Challenges and Rewards Part 1,” Biotechnology: Pharmaceutical Aspects (2007).
Sudha R. Vippagunta et al.: “Crystalline solids,” Advanced Drug Delivery Reviews 48 (2001) pp. 3-26.
Charles et al, “Synthesis of substituted Benzamides, Benzimidazoles and Benzoxazines as potential Anthelmintic and Antimicrobial Agents”, Archiv Der Pharmazie, 1982, 97-103, 315(2).
European Patent Office Additional Exemplary Search for Application No. EP 02 763 627.3 dated Apr. 26, 2007, 53 pages.
Ye et al., CNS Drug Rev., 2001 Summer, 7(2), 199-213.
STN International Search in U.S. Appl. No. 11/687,398, filed Feb. 10, 2008, 195 pages.
U.S. Appl. No. 12/043,450, filed Mar. 6, 2008.
Weidle et al., “XP-001098720—Inhibition of Histone Deacetylase: a New Strategy to Target Epigenetic Modification for Anticancer Treatment”, Anticancer Research 20, 2000, pp. 1471-1486.
U.S. Appl. No. 11/620,917, filed Jan. 8, 2007.
Graneb et al., “A Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase β, and Protein Kinase Cε*”, The Journal of Biological Chemistry, 273(48), 1998, 32016-32022.
Cecil Textbook of Medicine, edited by Bennett, J.C., and Plum F., 20thEdition, vol. 1, 1004-1010, (1996).
Ragione, Fulvio Della et al., “Genes Modulated by Histone Acetylation as New Effectors of Butyrate Activity”, FEBS Letters 499, 199-204, (2001).
Turner, W. W. et al., “Recent Advances in the Medicinal Chemistry of Antifungal Agents”, Current Pharmaceutical Design, 2, 209-224 (1996).
Sugar, Alan M. et al., “Comparison of Three Methods of Antifunal Susceptibility Testing with the Proposed NCCLS Standard Broth Macrodilution Assay: Lack of Effect of Phenol Red”, Diagn. Microbiol. Infect. Dis., 21, 129-133 (1995).
Snyder, JW et al., “Common Bacteria Whose Susceptibility to Antimicrobials is no Longer Predictable”, J. Med. Liban, 48(4), 208-14 (2000).
Suzuki, et al., “Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives,” Journal of Medicinal Chemistry, American Chemical Society, Washington U.S., vol. 42, No. 15, 1999, pp. 3001-3003.
Database Crossfire Beilstein (Online) Beilstein Institut zur Föerderung der Chemischen Wissenschaftern, Frankfurt am Main, DE, N,N′-di (o-aminophenyl) terephthalamide, Database accession No. 5619310 XP-002229372, Third invention Abstract & Indian J. Chem. Sect. B., vol. 25, 1986, pp. 1146-1149.
Database Crossfire Beilstein (Online) Beilstein Institut zur Föerderung der Chemischen Wissenschaften, Frankfurt am Main, DE, Database accession No. 3016237 XP-002229373, 4, 6-diamino-N, N′-bis-(2-amino-phenyl)-isophthalamide. Third invention abstract & Chem. Heterocycl. Compd. vol. 13, 1977, pp. 1029-1032.
Database Crossfire Beilstein (Online) Beilstein Institut zur Föerderung der Chemischen Wissenschaftern, Frankfurt am Main, DE, Database accession No. 3458834 XP-002229374, N, N′-bis-(2-amino-phenyl)-phthalamide. Third invention abstract & Justus Liebigs Ann. Chem., vol. 347, 1906, p. 116.
Picard et al., “Desymmetrization Reactions: A Convenient Synthesis of Aromatic Diamide Diamines” Synthesis, vol. 10, 2001, pp. 1471-1478.
Rabilloud G et al., “Réactions de condensation de l'o-phénylenediamine avec les benzoxazin-3, 1-ones-4 substituées en position 2”, Bull. Soc. Chim. Fr., 1975, pp. 2682-2686.
Csordas, Adam, “On the Biological Role of Histone Acetylation,” Biochem. J., vol. 265 (1990) pp. 23-38.
Taunton, Jack, et al. “A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p,” Science, vol. 272 (1996) pp. 408-411.
Grozinger, Christina M., et al., “Three Proteins Define a Class of Human Histone Deacetylases Related to Yeast Hda1p,” PNAS, vol. 96 (1999) pp. 4868-4873.
Kao, Hung-Ying, et al., “Isolation of a Novel Histone Deacetylase Reveals that Class I and Class II Deacetylases Promote SMRT-Mediated Repression,” Genes & Development, vol. 14 (2000) pp. 55-66.
Van den Wyngaert, Ilse, et al. “Cloning and Characterization of Human Histone Deacetylase 8,”

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of histone deacetylase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of histone deacetylase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of histone deacetylase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2638547

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.