Inhibitors of herpes viral ribonucleotide reductase

Details Inhibitors of herpes viral ribonucleotide reductase Inhibitors of herpes viral ribonucleotide reductase

1994-02-28

1995-12-19

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530329, 530330, A61K 3800, C07K 700, C07K 500, C07K 1700

Patent

active

054768411

ABSTRACT:
Peptide derivatives are of the formula A--B--D--NHCH{CH.sub.2 C(O)R.sup.1 }C(O)--NHCH{CR.sup.2 (R.sup.3)--COOH}C(O)--E wherein A is a lower alkanoyl bearing two substituents, each substituent selected independently from phenyl or a monosubstituted phenyl wherein the monosubstituent is alkyl, halo, hydroxy or alkoxy; B is a N-methyl amino acid residue; D is an amino acid residue; R.sup.1 is alkyl, cycloalkyl, a monosubstituted amino or a disubstituted amino; R.sup.2 is hydrogen or alkyl and R.sup.3 is alkyl, or R.sup.2 and R.sup.3 are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections.

REFERENCES:
Chang et al. Bioorganic & Medicinal Chem. Lett. vol. 2, p. 1207 (1992).

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