Inhibitors of GSK-3 and uses thereof

Details Inhibitors of GSK-3 and uses thereof Inhibitors of GSK-3 and uses thereof

2005-06-03

2008-11-18

Powers, Fiona T (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...

C514S333000, C514S341000, C514S407000, C534S753000, C534S766000, C534S769000, C534S774000, C534S775000, C544S140000, C546S256000, C546S276100, C548S365700, C548S367400, C548S370100

Reexamination Certificate

active

07452873

ABSTRACT:
The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.

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