Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-10-11
1979-12-11
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424314, A61K 3119
Patent
active
041783867
ABSTRACT:
2-Hydroxy-3-butynoic acid is disclosed which inhibits glycolic acid oxidase and thus is useful in the treatment and prevention of calcium oxalate urolithiasis (calcium oxylate kidney and bladder stone disease).
REFERENCES:
Chemical Abstracts 77:149049v (1972).
Jewess et al., Febs Letters 53, p. 292 (1975).
Cromartie et al., J. Chem. Soc., Chem. Comm. 597 (1974).
Ghisla et al., Biochemistry, 15, p. 1791 (1976).
Verny et al., Bulletin de la Societe Chimique de France, 6, p. 2210 (1967).
Cragoe, Jr. Edward J.
Rooney Clarence S.
Williams Haydn W. R.
Merck & Co. , Inc.
Schenkman Leonard
Sudol, Jr. Michael C.
Westlake, Jr. Harry E.
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