Inhibitors of glycogen synthase 3 kinase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S277000

Reexamination Certificate

active

07053097

ABSTRACT:
Compounds of formula 1:whereinR1is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0–3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro;R2is hydroxy, amino, or lower alkoxy;R3is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl;R4is H or lower alkyl;and pharmaceutically acceptable salts and esters thereof;are effective inhibitors of GSK3.

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