Inhibitors of glycogen synthase 3 kinase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514266, 544277, C07D47316, A61K 3152

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active

061536180

ABSTRACT:
Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro;
R.sub.2 is hydroxy, amino, or lower alkoxy;
R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl;
R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

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