Inhibitors of folic acid-dependent enzymes

Details Inhibitors of folic acid-dependent enzymes Inhibitors of folic acid-dependent enzymes

2011-01-25

2011-01-25

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S258000, C544S259000, C544S260000, C544S280000

Reexamination Certificate

active

07875716

ABSTRACT:
The invention relates to compounds of the formula I, or pharmaceutically acceptable salts thereof:wherein:Z=O or S;n=1-3;R3=—CO2R8, —C(O)SR8, —C(O)NHR8, —C(S)OR8, —C(S)SR8, —C(S)NHR8, —C(NH)SR8or —C(NH)NHR8,wherein R8is —H or alkyl;R4=—H, —CH2R5or —CH2CH2R5,wherein R5independently has one of the meanings of R3;B=—NR2—, —CH2NR2—, —CH2CH2NR2—, —CH2CHR7— or —CH2O—,wherein R2is H or a C1-3alkyl, alkenyl or alkynyl group, andR7is H or a C1-3alkyl or alkoxy group;wherein R1=—NH2or —OH, and C and D are each, independently, a 5- or 6-membered, substituted or unsubstituted, aromatic or non-aromatic ring which may also contain one or more heteroatoms, and C is connected to group B in any available position.

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