Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

1994-06-28

1996-04-23

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560147, 560155, 560174, 560179, 560205, 560226, 560312, 562 9, 562 10, 562 11, 562 15, 562 16, 562 23, 562 36, 562 37, 562 41, 562104, 562113, 562126, C07C 6902

Patent

active

055105106

ABSTRACT:
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula ##STR1## their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein:

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