Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-22
1999-08-17
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 546256, 544405, C07D40104, A61K 3144
Patent
active
059394390
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Anthony Neville J.
Bell Ian M.
deSolms S. Jane
Gomez Robert P.
Graham Samuel L.
Daniel Mark R.
Fan Jane
Merck & Co. , Inc.
Muthard David A.
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