Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

1991-12-16

1993-09-14

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

560190, 560193, 562595, C07C 59147, C07C 59185, C07C 6934, C07C 5702

Patent

active

052450619

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and method for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 5043268 (1991-08-01), Stock
Gill, M. "3-[(7Z)-hexadecenyl]-4-metholfuran-2,5-dione from Piptoporus australiensisis.", Phyto Chemistry, 21:1788-1788 (1982).
Turner, W. B., et al., "Secondary metabolites derived from intermediates of the tri-carboxylic acid cycle", Fungal metabolites II, Academic Press, pp. 367-383 (1983).
Biller, S. A., "The first potent inhibitor of squalene synthases: A profound contribution of an ether oxygen to inhibitor--Enzyme Interaction", J. Am. Chem. Soc., 113, 8522-8524 (1991).
Goldstein, J. L., et al., "Non farnesylated tetrapeptide inhibitor of protein farnesyl transferase", The Journal of Biological Chemistry, vol. 266, No. 24 pp. 15575-15578 (1991).

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