Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

1994-06-28

1996-04-02

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514399, 514602, 514605, 514630, 514617, 514618, 514620, 514649, 530323, 5483097, 564 84, 564 92, 564152, 564154, 564197, 564155, 564162, 564164, 564196, A61K 3116, C07C23706

Patent

active

055041159

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 5043268 (1991-08-01), Stock
patent: 5124322 (1992-06-01), Hughes
patent: 5331099 (1994-07-01), Stern et al.
patent: 5352705 (1994-10-01), Deana et al.
patent: 49296741 (1990-05-01), Haslanger et al.
Goldstein, J. L., et al., "Nonfarnsylated Tetrapeptide Inhibitors of Protein Farnesyltransferase", The Journal of Biological Chemistry, vol. 266, No. 24, pp. 15575-15578 (1991).
Kohl, N. E. et al., "Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice", Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9141-9145 (1994).

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