Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-27
1998-07-14
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514402, 5483144, 5483147, 5483361, 5483461, 5483245, 546343, A61K 31415, C07D40306, C07D40308, C07D40310, C07D40302, C07D23361
Patent
active
057804923
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Dinsmore Christopher J.
Williams Theresa M.
Daniel Mark R.
Higel Floyd D.
Merck & Co. , Inc.
Muthard David A.
Pecoraro Dianne
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