Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-29
1996-02-13
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514307, 514314, 514326, 514343, 514365, 514397, 514414, 514422, 514424, 514426, 514428, 546281, 546208, 546174, 546181, 546146, 546148, 546151, 548537, 548544, 548546, 548557, 548558, 548569, 5483147, 548518, A61K 3805, C07D20706, C07D20708, C07D20709
Patent
active
054911648
ABSTRACT:
The present invention comprises dipeptide analogs that inhibit the farnesylation of Ras. These farnesyl-protein transferase inhibitors are characterized by the inclusion of a cyclic amine in the backbone of the dipeptide. Further contained in this invention are chemotherapeutic compositions containing these farnesyl transferase inhibitors and methods for their production.
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deSolms S. Jane
Graham Samuel J.
Daniel Mark R.
Merck & Co. , Inc.
Muthard David A.
Richter Johann
Stockton Laura L.
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