Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-03-25
1999-01-12
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
574255, 544360, 544363, 544372, 544367, 544370, 544373, 544392, A61K 31495, C07D40306, C07D40106
Patent
active
058590129
ABSTRACT:
The present invention is directed to piperazine-2,3-dione compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Dinsmore Christopher J.
Williams Theresa M.
Bernhardt Emily
Daniel Mark R.
Merck & Co. , Inc.
Muthard David A.
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