Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-01
1999-04-06
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514318, 546210, 546194, C07D40108, A61K 31445
Patent
active
058918892
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
REFERENCES:
patent: 3764690 (1973-10-01), Draber et al.
patent: 5159083 (1992-10-01), Thurkauf et al.
patent: 5256682 (1993-10-01), Kruger et al.
patent: 5326780 (1994-07-01), Sugimoto et al.
patent: 5478934 (1995-12-01), Yuan et al.
patent: 5576313 (1996-11-01), Fisher et al.
patent: 5639775 (1997-06-01), Durant et al.
Exp. Opin. Ther. Patents, vol. 5(12), pp. 1269-1271 (1995), by S. L. Graham.
Exp. Opin. Ther. Patents, vol. 6(12) (1996), pp. 1295-1304, by S. L. Graham, et al.
J. of Biol. Chem., vol. 268, No. 11, pp. 7617-7620 (1993), by J. B. Gibbs, et al.
J. of Biol. Chem., vol. 269, No. 44, pp. 27706-27714 (1994), by G. L. James, et al.
J. of Biol. Chem., vol. 270, No. 11, pp. 6221-6226 (1995), by G. L. James, et al.
Science, vol. 260, pp. 1934-1937 (1993), by N. E. Kohl, et al.
Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9141-9145 (1994), by N. E. Kohl, et al.
Nature Medicine, vol. 1, No. 8, pp. 792-797 (1995), by N. E. Kohl, et al.
Cancer Research, vol. 55, pp. 54302-5309 (1995), by L. Sepp-Lorenzino, et al.
Anthony Neville J.
Embrey Mark W.
Fisher Thorsten E.
Gomez Robert P.
Wai John S.
Daniel Mark R.
Fan Jane
Merck & Co. , Inc.
Muthard David A.
LandOfFree
Inhibitors of farnesyl-protein transferase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of farnesyl-protein transferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of farnesyl-protein transferase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1371650