Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-13
1996-01-02
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514357, 514399, 514562, 514450, 514459, 514461, 514432, 549271, 549293, 549295, 549 28, 549 9, 549 59, 549 65, 546268, 546283, 546284, 5483111, 5483151, 5483154, 530331, A61K 3144, A61K 31415, C07D31304
Patent
active
054808936
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Goldstein, J. L. et al., Nonfamesylated Tetrapeptide Inhibitors of Protein Farnesyltransferase*, (1991), Jour. of Biol. Chem., 266, pp. 15575-15578.
Reiss, Y., et al., Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase (1991), Proc. Natl. Acad. Sci., USA, 88, pp. 732-736.
Kohl, N. E. et al., "Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice", Proc. Natl. Acad. Sci., USA, vol. 91, pp. 9141-9145, (1994).
deSolms S. Jane
Graham Samuel L.
Daniel Mark R.
Ivy C. Warren
Merck & Co. , Inc.
Muthard David A.
Owens A. A.
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