Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

1993-06-09

1994-09-27

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

560190, 560193, 562595, C07C 59147, C07C 59185, C07C 6934, C07C 5702

Patent

active

053508670

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
Selva, et al., Chemical Abstracts, vol. 94, No. 19, (1981) Abstract No. 155848X.
A. Selva et al., New Secondary Metabolites of Aspergillus Wentii Wehmer; Biomed. Mass Spectrom., 7 148-152 (1980).

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