Inhibitors of farnesyl protein transferase

Details Inhibitors of farnesyl protein transferase Inhibitors of farnesyl protein transferase

1991-12-16

1993-11-09

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560193, 562595, 554121, C07C 6934, C07C 6952, C07C 5702, C07C 59235

Patent

active

052604799

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 5043268 (1991-08-01), Stock
Gill, M. "3-[(7)-hexadecenyl]-4-metholfuran-2,5-dione from Piptoporus australienisis.", Phyto Chemistry, 21:1788-1788 (1982).
Turner, W. B., et al., "Secondary metabolites derived from intermediates of the tri-carboxlyic acid cycle", Fungal metabolites II, Academic Press, pp. 367-383 (1983).
Biller, S. A., "The first potent inhibitor of squalene synthase: A profound contribution of an ether oxygen to inhibitor--Enzyme Interaction", J. Am. Chem. Soc., 113, 8522-8524 (1991).
Goldstein, J. L., et al., "Non farnesylated tetrapeptide inhibitor of protein farnesyl transferase", The Journal of Biological Chemistry, vol. 266, No. 24 pp. 15575-15578 (1991).

Affiliated with

Also associated with

Rating

Inhibitors of farnesyl protein transferase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of farnesyl protein transferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of farnesyl protein transferase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1144458