Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-25
1999-07-06
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544370, 544366, C07D23354, C07D24108, A61K 31495, A61K 31415
Patent
active
059197854
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Bergman Jeffrey
Dinsmore Christopher J.
Williams Theresa M.
Daniel Mark R.
Merck & Co. , Inc.
Muthard David A.
Raymond Richard L.
Sripada Pavanaram K
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