Inhibitors of farnesyl-protein transferase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544370, 544360, 544357, 544364, 544231, 544384, 544391, 540492, 540575, 514218, 514255, A61K 31495, C07D40306, C07D40106, C07D24104

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058563261

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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