Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-10-29
1994-07-05
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514397, 514450, 514459, 514471, 546268, 546283, 5483154, 5483111, 5483131, 549271, 549293, 549321, A61K 3144, A61K 31415, A61K 31335, C07D31304
Patent
active
053267737
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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patent: 5216013 (1993-06-01), Hanson
patent: 5217991 (1993-06-01), Hanson et al.
patent: 5238922 (1993-08-01), Graham et al.
Goldstein, J. L., et al., "Nonfarnesylated Tetrapeptide Inhibitors of Protein Farnesyltransferase", The Journal of Biological Chemistry, vol. 266, No. 24 pp. 15575-15578 (1991).
de Solms S. Jane
Graham Samuel L.
Daniel Mark R.
DiPrima Joseph F.
Ivy C. Warren
Merck & Co. , Inc.
Owens A. A.
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