Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-10-05
2000-10-03
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544130, A61K 31535, C07D41306
Patent
active
06127366&
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the famesylation of the oncogene protein Ras.
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Ciccarone Terrence M.
deSolms S. Jane
Graham Samuel L.
Kim Byeong M.
Shaw Anthony W.
Daniel Mark R.
Fan Jane
Garcia-Rivas J. Antonio
Merck & Co. , Inc.
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