Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1992-06-26
1994-10-04
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
435 15, 514399, 514602, 514605, 514616, 514617, 514618, 514620, 514649, 530323, 5483097, 564 84, 564 92, 564152, 564155, 564162, 564164, 564196, 564197, A61K 3116, C07C23706
Patent
active
053527054
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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Goldstein, J. L., et al., "Nonfarnesylated Tetrapeptide Inhibitors of Protein Farnesyltransferase", The Journal of Biological Chemistry, vol. 266, No. 24 pp. 15575-15578 (1991).
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Reiss et al. PNAS. vol. 88, 732-736, 1991.
Deana, deceased Albert A.
deSolms S. Jane
Graham Samuel L.
Smith Robert L.
Daniel Mark R.
DiPrima Joseph F.
Kumar Shailendra
Merck & Co. , Inc.
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