Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-09-30
1994-08-23
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514399, 514562, 514 2, 546335, 5483127, 5483131, 5483151, 5483157, 5483111, 5483385, 562426, 562500, 562508, 562553, 562556, 562557, 562559, 530331, A61K 3144, A61K 31415, A61K 31195
Patent
active
053408284
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
REFERENCES:
patent: 4801609 (1989-01-01), Haslanger et al.
patent: 4855286 (1989-08-01), Wagner et al.
patent: 4879309 (1989-11-01), Doll et al.
patent: 4929641 (1990-05-01), Haslanger et al.
patent: 4931591 (1990-06-01), Buhlmayer et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5043268 (1991-08-01), Stock
patent: 5081284 (1992-01-01), Higuchi et al.
Reiss, et al., Proc. Natl. Acad. Sci., USA, vol. 88, pp. 732-736 (1991).
Goldstein, J. L., et al., "Nonfarnesylated Tetrapeptide Inhibitors of Protein Farnesyltransferase", The Journal of Biological Chemistry, vol. 266, No. 24 pp. 15575-15578 (1991).
deSolms S. Jane
Graham Samuel L.
Daniel Mark R.
DiPrina Joseph F.
Ivy C. Warren
Merck & Co. , Inc.
Owens A. A.
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