Inhibitors of factor Xa and other serine proteases involved...

Details Inhibitors of factor Xa and other serine proteases involved... Inhibitors of factor Xa and other serine proteases involved...

2005-04-18

2008-08-05

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S350000, C514S423000, C514S343000, C514S314000, C514S210030, C514S234200, C544S335000, C546S167000, C546S208000, C546S256000, C546S279100, C548S254000, C548S255000, C548S269400, C548S314700, C548S364100, C548S538000, C548S567000

Reexamination Certificate

active

07407974

ABSTRACT:
The present invention provides compounds of Formula (I):wherein A, B, C, G, and W1have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.

REFERENCES:
patent: 4559157 (1985-12-01), Smith et al.
patent: 4608392 (1986-08-01), Jacquet et al.
patent: 4820508 (1989-04-01), Wortzman
patent: 4938949 (1990-07-01), Borch et al.
patent: 4992478 (1991-02-01), Geria
patent: 5807875 (1998-09-01), Rudolf et al.
patent: 2002/0091116 (2002-07-01), Zhu et al.
patent: 23/99018 (2001-02-01), None
patent: WO 95/28420 (1995-10-01), None
patent: WO 97/05161 (1997-02-01), None
patent: WO97/19911 (1997-06-01), None
patent: WO 97/46576 (1997-12-01), None
patent: WO 98/50029 (1998-11-01), None
patent: WO 01/19788 (2001-03-01), None
patent: WO 01/19798 (2001-03-01), None
patent: WO 01/64642 (2001-09-01), None
patent: WO 01/96296 (2001-12-01), None
patent: WO 02/00651 (2002-01-01), None
patent: WO 02/08177 (2002-01-01), None
patent: WO 02/24654 (2002-03-01), None
patent: WO 02/30880 (2002-04-01), None
patent: WO 02/48099 (2002-06-01), None
patent: WO 02/057236 (2002-07-01), None
Massey, et al., Stroke 1990: 1289-1292.
Two page Abstract of Kotze, et al., Thromb. Haemost.,1997, vol. 77, No. 6, 1137-1142.
Two page Abstract of Mismetti, et al., Thromb. Haemost., Jun. 1998; 79 (6): 1162-5.
One page Abstract of Bostwick, et al. Thromb. Haemost. Jan. 1999; 81 (1): 157-60.
Antman, et al., Circulation, 1999; 100; 1602-1608.
Circulation, Nov. 28, 2000; 102(22): 2726-31.
Coussement, et al., Europ. Heart J., 2001, 22, 1716-1724.
Wang, et al., Stroke 2003; 34; 468-474.
Two page Abstract of Shu, et al. Phathophysiol. Haemost. Thromb. 2003-2004, vol. 33, No. 4, 206-213.
Thrombosis Research 111, 2003, 133-135.
Two page Abstract of Leone, et al., Curr. Med. Chem. Cardiovasc. Hematol. Agents; Oct. 2004; 2(4):311026.
“Prevent” (Webster's Comprehensive Dictionary, 1996.
Wiikipedia, “thrombotic microangiopathies,” Feb. 2006.
Wikipedia, “thrombotic thrombopcytopenic purpura,” Feb. 2007.
Wikipedia, “post-thrombotic syndrome,” Dec. 2006.
Wikipedia, “protein C deficiency,” Feb. 2007.
Wikipedia, “Libman-Sacks endocarditis,” Nov. 2006.
Wikipedia, “poikilocytosis,” Feb. 2007.
Wikipedia, “phlegmasia cerulea dolens,” Jan. 2007.
Printout from the Wikipedia website, <http://en.wikipedia.org/wiki/Template:Congenital—malformations—and—deformations—of—circulatory—system> , downloaded Jul. 23, 2007.
Printout from the Wikipedia website, <http://en.wikipedia.org/wiki/Thrombosis>, downloaded Jul. 23, 2007.
Printout from the Leukemia & Lymphoma Society website, <http://www.leukemia-lymphoma.org/all—page?item—id=7026>, downloaded Jul. 12, 2007.
Printout from the Leukemia & Lymphoma Society website, <http://www.leukemia-lymphoma.org/all—page?item—id=7030&viewmode=print>, downloaded Jul. 13, 2007.
Printout from the American Diabetes Assn. Website, http://www.diabetes.org/gestational-diabetes.jsp, downloaded Jul. 16, 2007.
Printout from the Diabetes Insipidus Found. website, http://www.diabetesinsipidus.org/, downloaded Jul. 22, 2007.
BBC News/Health, Killer Breast Cancer Therapy Hope, <http:/
ewsvote.bbc.co.uk/mpapps/pagetooles/print
ews.bbc.co.uk/1/hi/health/4619900.stm>, downloaded Jan. 31, 2007.
Camerer, et al., J. Biol. Chem., 10, 1074/jbc.M108555200 (abstract).
Jiang, et al., J. Thrombosis & Haemostasis, 2: 93-101 (2003).
Tanaka, et al., Kidney Intern'l., vol. 67 (2005), pp. 2123-2133.
Versteeg, et al., Molec. Med., Jan.-Jun. 2004, vol. 10, pp. 6-11.
(<<http://www.uspto.gov/web/offices/pac/dapp/1pecba.htm#7>> Enablement Decision Tree, Example F, situation 1.
Printout from the Cleveland Clinic website, <http://clevelandclinicmeded.com/diseasemanagement/cardiology/vthromboembolism/vthro . . . >, downloaded Jul. 23, 2007.
Printout from the American Diabetes Assn. Website, http://www.diabetes.org/utils/printthispage.jsp?PageID=TYPE1DIABETES3—233168, downloaded Jul. 16, 2007.
Printout from the American Diabetes Assn. Website, http://www.diabetes.org/utils/printthispage.jsp?PageID=TYPE2DIABETES3—233169 downloaded Jul. 16, 2007.
Lapatto et al., Embo. J, 1997:5151-5161.
Mellott et al, Fibrinolysis, 1993: 195-202.
Lynch et al., Thromb. Haemostasis, 1995:640-645.
Schaffer et al., Circulation, 1991: 1741-1748.
Fioravanti et al., Thromb. Res., 1993: 317-324.
Wong et al., Thromb. Res., 1996: 117-126.
Leadley, Curr. Top. Med. Chem., 2001: v. 1, 151-159.
Edmunds et al., Annual Reports in Medicinal Chemistry, 1996:51.
Kunitada and Nagahara, Curr. Pharm. Des., 1996:531-542.
Berge S.M. et al.,Pharmaceutical Salts, Journal of Pharmaceutical Science, 1977;66:1-19.
F Al-Obeidi & Jaostrem: “Factor Xa Inhibitors” Expert Opinion on Therapeutic Patents., vol. 9, No. 7, 1999, pp. 931-953, XP001000512.
Erik Verner et al.: “Development of Serine Protease Inhibitors Displaying a Multicenter Short Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa” Journal of Medicinal Chemistry vol. 44, No. 17, 2001, pp. 2753-2771, XP002216503.
Michael R Wiley et al., “Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa: Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity” Journal of Medicinal Chemistry, vol. 43, No. 5, 2000, pp. 883-899, XP002186966.
Ying K. Yee et al.,: “N-Aroylanthranilamide Inhibitors of Human Factor Xa” Journal of Medicinal Chemistry., vol. 43, No. 5, 2000, pp. 873-882, XP002186965.

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