Inhibitors of factor Xa

Details Inhibitors of factor Xa Inhibitors of factor Xa

1993-12-15

1999-03-16

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 518 18, C07K 506

Patent

active

058830774

ABSTRACT:
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The novel compounds include peptide aldehyde analogues having substantial potency and specificity as inhibitors of mammalian factor Xa are further disclosed. The compounds are thought useful as inhibitors of factor xa in vitro or as a therapeutic agent for the prevention and treatment of conditions characterized by abnormal thrombosis in mammals. Intermediates useful for the preparation of the novel compounds are also disclosed.

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patent: 5367072 (1994-11-01), Webb
Ripka et al., Strategies in the Design of Inhibitors of Serine Proteases of the Coagulation Cascade-Factor Xa, Eur. J. Med. Chem., Supplement to vol. 20, pp. 87s-110s (1995).
R.M. McConnell et al., Journal of Medicinal Chemistry 33:1, pp. 86-93 (Jan. 1990).
A.M. Murphy et al., Journal of American Chemical Society 114:8, pp. 3156-3157 (Apr. 1992).
R.M. McConnell et al., Journal of Medicinal Chemistry 36:8, pp. 1084-1089 (Apr. 1993).

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