Inhibitors of endothelin-1 synthesis

Details Inhibitors of endothelin-1 synthesis Inhibitors of endothelin-1 synthesis

2002-11-18

2008-09-09

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07423141

ABSTRACT:
Sequences in human preproendothelin-1 mRNA are described against which antisense oligonucleotides can be used to inhibit the synthesis of endothelin-1. This inhibition of endothelin-1 synthesis may be used to treat diseases where excess production of endothelin-1 is an underlying cause of the symptoms.

REFERENCES:
patent: 4306075 (1981-12-01), Aristoff
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5602204 (1997-02-01), Harimoto et al.
patent: 5688499 (1997-11-01), Banting et al.
patent: 5747340 (1998-05-01), Harats et al.
patent: 5994076 (1999-11-01), Chenchik et al.
patent: 6054486 (2000-04-01), Crow et al.
patent: 6551795 (2003-04-01), Rubenfield et al.
patent: 0 347 243 (1989-12-01), None
patent: WO 92/20823 (1992-11-01), None
patent: WO 9608268 (1996-03-01), None
patent: WO 99/11778 (1999-03-01), None
D'Orleans-Juste et al. (1997) Mol. Cell. Biochemistry 172:199-211.
Kurreck (2003) Eur. J. Biochem. 270:1628-1644.
Lin et al. (2002) J. Cardiovascular Pharmacology 39:590-599.
Gerwirtz et al. (1998) Blood 92(3):712-736.
Jen et al. (2000) Stem Cells 18:307-319.
Opalinska et al. (2002) Nature Reviews 1 :503-514.
Schriffin et al. (1997) J. Hypertension 15:57-63.
Weir (1998) AJH 11:163S-169S.
K.M. McCulloch et al., British Journal of Pharmacology, “Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: effect of chronic hypoxia in the rat,” vol. 123, pp. 1621-1630 (1998).
B.M. Löffler et al., Federation of European Biochemical Societies, “Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma,” vol. 333, No. 1,2, pp. 108-110 (1993).
T. Fukuroda et al., Biochemical and Biophysical Research Communications, “Clearance of Circulating Endothelin-1 by ETB Receptors in Rats,” vol. 199, No. 3, pp. 1461-1465 (1994).
P.J. Barnes, Br. J. Clin. Pharmacol, “Pathophysiology of asthma,” vol. 42, pp. 3-10 (1996).
P.J. Barnes, Brief Review, “Endothelins and pulmonary diseases,” pp. 1051-1059 (1994).
M.J. Carr et al., European Respiratory Journal, “Distribution of immunoreactive endothelin in the lungs of mice during respiratory viral infection,” vol. 11, pp. 79-85 (1998).
K.R. Chapman et al., The American Journal of Medicine, “Therapeutic Approaches to Chronic Obstructive Pulmonary Disease: An Emerging Consensus,” vol. 100, Suppl. 1A, pp. 1A-5S-1A-10S (1996).
S.J. Chen et al., Journal of Cardiovascular Pharmacology, “The Orally Active Nonpeptide Endothelin A-Receptor Antagonist A-127722 Prevents and Reverses Hypoxia-Induced Pulmonary Hypertension and Pulmonary Vascular Remodeling in Sprague-Dawley Rats,” vol. 29, pp. 713-725 (1997).
R. Corder et al., Journal of Cardiovascular Pharmacology, “Cytokine Regulation of Endothelin-1 Release from Bovin Aortic Endothelial Cells,” vol. 26, Suppl. 3, pp. S56-S58 (1995).
V.S. diCarlo et al., “ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat,” pp. L690-L697 (1995).
A. Giaid et al., The New England Journal of Medicine, “Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension,” vol. 333, No. 4, pp. 214-221 (1995).
D. W.P. Hay et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 284, No. 2, “Functional and Binding Characterization of Endothelin Receptors in Human Bronchus: Evidence for a Novel Endothelin B Receptor Subtype?,” pp. 669-677 (1998).
W.G. Haynes et al., Journal of Hypertension, vol. 16, No. 8, “Endothelin-1 as a regulator of cardiovascular function in health anthesease,” pp. 1081-1098 (1998).
M. Hoshino et al., Thorax, vol. 53, “Expression of growth factors and remodelling of the airway wall in bronchial asthma,” pp. 21-27 (1998).
P.K. Jeffery, Thorax, vol. 53, “Structural and inflammatory changes in COPD: a comparison with asthma,” pp. 129-136 (1998).
A. Jeppsson et al., Transplantation, vol. 66, No. 6, “Distribution of Endothelin-I in Transplanted Human Lungs,” pp. 806-809 (1998).
P. Klemm et al., Proc. Natl. Acad. Sci. USA, vol. 92, “Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines,” pp. 2691-2695 (1995).
K. Malarkey et al., British Journal of Pharmacology, vol. 116, “Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells,” pp. 2267-2273 (1995).
M. Marini et al., Biochemical and Biophysical Research Communications, vol. 220, “Endothelin-1 Induces Increased Fibronectin Expression in Human Bronchial Epithelial Cells,” pp. 896-899 (1996).
B.E. Marshall et al., The Lung: Scientific Foundations, Chapter 5.2.6, “Pulmonary Hypertension,” pp. 1177-1187 (1991).
C.D. McDermott et al., Journal of Cardiovascular Pharmacology, vol. 31, Suppl. 1, “Immunohistochemical Localization of Endothelin-1 and Endothelin-Converting Enzyme-1 in Rat Lung Allografts,” pp. S27-S30 (1998).
J.W. Nyce et al., Nature, vol. 385, “DNA antisense therapy for asthma in an animal model,” pp. 721-725 (1997).
M. Nootens et al., JACC, vol. 26, No. 7, “Neurohormonal Activation in Patients With Right Ventricular Failure From Pulmonary Hypertension: Relation to Hemodynamic Variables and Endothelin Levels,” pp. 1581-1585 (1995).
R.A. Panettieri, Jr. et al., British Journal of Pharmacology, vol. 118, “Endothelin-1 induced potentiation of human airway smooth muscle proliferation: an ETAreceptor-mediated phenomenon,” pp. 191-197 (1996).
D.J. Riley, The Lung: Scientific Foundations, Chapter 5.2.7, “Vascular Remodeling,” pp. 1189-1198 (1991).
A.E. Redington et al., J. Allergy Clin. Immunol., vol. 100, No. 4, “Immunoreactive endothelin in bronchial biopsy specimens: Increased expression in asthma and modulation by corticosteroid therapy,” pp. 544-552 (1997).
C.R. Roberts, “Is Asthma a Fibrotic Disease?,” Chest, vol. 107, No. 3, Session 4, 37th Annual Aspen Lung Conference, pp. 111S-117S (1995).
G. Sun et al., Peptides, vol. 18, No. 9, “Endothelin-1 Induces Bronchial Myofibroblast Differentiation,” pp. 1449-1451 (1997).
S. Takeda et al., Ann Thorac Surg., vol. 63, “Experimental Bronchiolitis Obliterans Induced by In Vivo HVI-Liposome-Mediated Endothelin-1 Gene Transfer,” pp. 1562-1567 (1997).
D.C. Underwood et al., Journal of Cardiovascular Pharmacology, “Chronic Hypoxia-Induced Cardiopulmonary Changes in Three Rat Strains: Inhibition by the Endothelin Receptor Antagonist,” vol. 31, Suppl. 1, pp. S453-S455 (1998).
D.C. Underwood et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 283, No. 3, “Nonpeptide Endothelin Receptor Antagonists. X. Inhibition of Endothelin-1- and Hypoxia-Induced Pulmonary Pressor Responses in the Guinea Pig by the Endothelin Receptor Antagonist, SB 217242,” pp. 1130-1137 (1997).
B.R. Wiggs et al., “On the mechanism of mucosal folding in normal and asthmatic airways,” pp. 1814-1821 (1997).
J.F. Milligan et al., Journal of Medicinal Chemistry, vol. 36, No. 14, “Current concepts in Antisense Drug Design,” pp. I923, 1993).
Y. Itoh et al., Federation of European Biochemical societies, vol. 231, No. 2, “Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin,” pp. 440-444 (1988).
Corder et al., Biochemical and Biophysical Research Communications, vol. 207, No. 1, “A simple method for isolating human endothelin converting enzyme free from contamination by neutral endopeptidase 24.11,” pp. 355-362 (1995).
C-J. S. Edgell et al., Proc., Natl. Acad. Sci. USA, vol. 80, “Permanent cell line expressing

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