Inhibitors of E-, P- and L-selectin binding

Details Inhibitors of E-, P- and L-selectin binding Inhibitors of E-, P- and L-selectin binding

1996-10-28

1998-11-03

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514459, 514460, 435105, 435125, 536 172, 536117, 549222, A61K 3170, C12P 1902

Patent

active

058308717

ABSTRACT:
Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition reaction is catalyzed by aldolase. The inhibitors exhibit an activity comparable to sialyl Lewis X with respect to the E-selectin binding assay and high activities in the P- and L-selectin binding assays. The inhibitors are employable for blocking neutrophil inflamatory conditions.

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