Inhibitors of dipeptidyl peptidase IV

Details Inhibitors of dipeptidyl peptidase IV Inhibitors of dipeptidyl peptidase IV

2007-03-13

2007-03-13

Tucker, Zachary C. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S343000, C514S423000

Reexamination Certificate

active

10221129

ABSTRACT:
Compounds according to general formula (1), wherein R1is H or CN, X1is S, O, SO2or CH2, X2is O, S or CH2, X3is NR5or a carbonyl or thiocarbonyl group and R4is R6R7N, R8(CH2)qOC(═O), R8(CH2)qOC(═S), R6R7NC(═O), R6R7NC(═S); R8(CH2)qC(═O), R8(CH2)qC(═S) or R8(CH2)qSO2, m is 1–3 and n is 0–4 are new. The compounds of the invention are inhibitors of dipeptidyl peptidase IV. Pharmaceutical compositions of the compounds of the invention, or pharmaceutically acceptable salts thereof, are useful in the treatment of, inter alia, type 2 diabetes

REFERENCES:
patent: 4696913 (1987-09-01), Geiger et al.
patent: 5939560 (1999-08-01), Jenkins et al.
patent: 6011155 (2000-01-01), Villhauer
patent: 6548481 (2003-04-01), Demuth et al.
patent: 6716843 (2004-04-01), De Nanteuil et al.
patent: 198 26 972 (1999-12-01), None
patent: 199 40 130 (2001-03-01), None
patent: 0 490 379 (1992-06-01), None
patent: WO 88/19998 (1998-05-01), None
patent: WO 99 61431 (1999-12-01), None
Translation of WO 99/61431, Schreiber Translations, Inc., PTO-05-3456, May 2005.
Reinhold, D. et al., “Inhibitors of Dipeptidyl Peptidase IV (DP IV, CD26) Specifically Suppress Proliferation and Modulate Cytokine Production of Strongly CD26 Expressing U937 Cells”,Immunobiology,Fischer, Stuttgart, DE, vol. 192, No. 1/02, 1994, pp. 121-136, XP000870158, ISSN: 0171-2985.
Augustyns, K. et al., “The Unique Properties of Dipeptidyl-Peptidase IV (DPP IV/CD26) and the Therapeutic Potential of DPP Inhibitors”,Current Medicinal Chemistry, Be, Bentham Science Publishers BV, vol. 6, No. 4, 1999, pp. 311-327, XP000870290, ISSN: 09298673.
Ashworth, D.M. et al., “2-Cyanopyrrolidides as Potent, Stable Inhibitors of Dipeptidyl Peptidase IV”,Bioorganic&Medical Chemistry Letters, Oxford, GB, vol. 6, No. 10, 1996, pp. 1163-1166, XP000953254, ISSN: 0960-894X.
Ashworth, D.M. et al., “4-Cyanothlazolidides As Very Potent, Stable Inhibitors of Dipeptidyl Peptidase IV”,Bioorganic&Medicinal Chemistry Letters, Oxford, GB, vol. 6, No. 22, 1996, pp. 2745-2748,, XP000957892, ISSN:0960-894X.
Schoen, E. et al., “Dipeptidyl Peptidase IV in The Immune System. Effects of Specific Enzyme on Activity of Dipeptidyl Peptidase IV and Proliferation of Human Lymphocytes”,Biological Chemistry, Hoppe-Seyler, De, Walter DE Gruyter, Berlin, vol. 372, No. 5, May 1991, pp. 305-311, XP000874047, ISSN: 0177-3593.
Demuth, H.-U. et al., Design of (Omega-N-(O-Acyl)Hydroxy Amid) Aminodicarboxylic Acid Pyrrolidides As Potent Inhibitors of Proline-Specific Peptidases:,FEBS Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 320, No. 1, Mar. 1993, pp. 23-27, XP001007983, ISSN: 0014-5793.

Affiliated with

Also associated with

Rating

Inhibitors of dipeptidyl peptidase IV does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of dipeptidyl peptidase IV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of dipeptidyl peptidase IV will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3724774