Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-12-05
2006-12-05
Russel, Jeffrey Edwin (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S019300, C530S300000, C560S312000, C560S315000
Reexamination Certificate
active
07144856
ABSTRACT:
The present invention relates to specific inhibitors of the cysteine protease dipeptidyl peptidase I (DP I)which can be used in the treatment of malignant cell degeneration, immune diseases impaired wound healing and metabolic diseases of humans and are represented by the general formulaand the pharmaceutical salts thereof, in which R is a peptide or a branched or unbranched C1–C9alkyl chain, a branched or unbranched C2–C9alkenyl chain, a branched or unbranched C2–C9alkynyl chain, a C3–C9cycloalkyl, C4–C9carbocyclic, C5–C14aryl, C3–C9heteroaryl, C3–C9heterocyclic, all of the above residues optionally being substituted, the residue AS—AS is a dipeptide or a mimetic thereof, AS is an amino acid or a peptide mimetic thereof. The amino acid is peptide bound with R and R′ is a branched or unbranched C1–C9alkyl chain, a branched or unbranched C2–C9alkenyl chain, a branched or unbranched C2–C9alkynyl chain, a C3–C9cycloalkyl, C4–C9cycloalkenyl, C2–C9heterocycloalkyl, C3–C9heterocycloalkenyl, C5–C14aryl, C3–C9heteroaryl, C3–C9heterocyclic, whereas the heterocycloalkyl, heterocycloalkenyl, heteroaryl, heterocyclic residue can have up to 6 hetero ring atoms, an amino acid or a peptide mimetic thereof, all of the above residues may be optionally substituted, or is H.
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J. Lin et al
Demuth Hans-Ulrich
Heiser Ulrich
Niestroj Andre
Probiodrug (AG)
Russel Jeffrey Edwin
Sonnenschein Nath & Rosenthal LLP
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