Inhibitors of dipeptidyl peptidase I

Details Inhibitors of dipeptidyl peptidase I Inhibitors of dipeptidyl peptidase I

2005-01-18

2005-01-18

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S019300, C530S300000, C560S312000, C560S315000

Reexamination Certificate

active

06844316

ABSTRACT:
The present invention relates to specific inhibitors of the cysteine protease dipeptidyl peptidase I (DP I), which can be used in the treatment of malignant cell degeneration, immune deseases impaired wound healing and metabolic diseases of humans and are represented by the general formulain which R is a peptide or a branched or unbranched C1-C9alkyl chain, a branched or unbranched C2-C9alkenyl chain, a branched or unbranched C2-C9alkynyl chain, a C3-C9cycloalkyl, C4-C9carbocyclic, C5-C14aryl, C3-C9heteroaryl, C3-C9heterocyclic, all of the above residues optionally being substituted, the residue AS—AS is a dipeptide or a mimetic thereof, AS is an amino acid or a peptide mimetic thereof. The amino acid is peptide bound with R and R′ is a branched or unbranched C1-C9alkyl chain, a branched or unbranched C2-C9alkenyl chain, a branched or unbranched C2-C9alkynyl chain, a C3-C9cycloalkyl, C4-C9cycloalkenyl, C2-C9heterocycloalkyl, C3-C9heterocycloalkenyl, C5-C14aryl, C3-C9heteroaryl, C3-C9heterocyclic, whereas the heterocycloalkyl, heterocycloalkenyl, heteroaryl, heterocyclic residue can have up to 6 hetero ring atoms, an amino acid or a peptide mimetic thereof, all of the above residues may be optionally substituted, or is H.

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