Inhibitors of dipeptidyl-aminopeptidase type IV

Details Inhibitors of dipeptidyl-aminopeptidase type IV Inhibitors of dipeptidyl-aminopeptidase type IV

1993-07-15

1995-10-31

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 514 17, 514 18, 514 85, 514 89, 514 69, 514210, A61K 3800, A61K 31675, A01N 5700, A01N 6500

Patent

active

054629284

ABSTRACT:
The invention features an inhibitor of DP-IV, having the structure: ##STR1## wherein m is an integer between 0 and 10, inclusive; A and A' are L-amino acid residues such that the A in each repeating bracketed unit can be a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A' and C, and between A' and N are peptide bonds; and each X.sup.1 and X.sup.2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group at physiological pH.

REFERENCES:
patent: 4935493 (1990-06-01), Bachovchin et al.
Blumenstein et al, Biochem. Biophys. Res. Comm. vol. 163, pp. 980-987.
ASM News vol. 56 p. 368 (1990).

Affiliated with

Also associated with

Rating

Inhibitors of dipeptidyl-aminopeptidase type IV does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of dipeptidyl-aminopeptidase type IV, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of dipeptidyl-aminopeptidase type IV will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1772310