Inhibitors of cyclin dependent kinases

Details Inhibitors of cyclin dependent kinases Inhibitors of cyclin dependent kinases

1995-10-31

1998-03-31

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514254, 514256, 514274, 514312, 514320, 514324, 514432, 514456, 544238, 544315, 544318, 544408, 546153, 546196, 5462831, 549 23, 549401, 549403, A61K 3144, C07D40502

Patent

active

057339201

ABSTRACT:
The invention provides novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cyclin D1. The novel compounds are analogs of chromones. These compounds can be used for inhibiting excessive or abnormal cell proliferation. Thus, the novel compounds are useful for treating a subject with a disorder associated with excessive cell proliferation, such as cancer.

REFERENCES:
patent: 4603137 (1986-07-01), Bhat et al.
patent: 4900727 (1990-02-01), Kattige et al.
patent: 5284856 (1994-02-01), Naik et al.
Losiewicz, Michael, et al., "Potent Inhibition of CDC2 Kinase Activity By The Flavonoid L86-8275", Biochemical and Biophysical Research Communications, vol. 201, No. 2, pp. 589-595 (1994).
Vlahos, Chris J., et al., "A Specific Inhibitor of Phosphatidylinositol 3-Kinase, 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)", The Journal of Biological Chemistry , vol. 269, No. 7, pp. 5241-5248 (1994).
Worland, Peter J., et al., "Alteration of the Phosphorylation State of p34.sup.cdc2 Kinase by the Flavone L86-8275 In Breast Carcinoma Cells", Biochemical Pharmacology , vol. 46, No. 10, pp. 1831-1940 (1993).

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