Inhibitors of cholesterol esterase

Details Inhibitors of cholesterol esterase Inhibitors of cholesterol esterase

1999-12-16

2000-09-05

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549302, C07D30783, C07D31120, C07D31174

Patent

active

061145459

ABSTRACT:
The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.

REFERENCES:
patent: 4749798 (1988-06-01), Gandolfi et al.
patent: 5464824 (1995-11-01), Gaudin

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