Inhibitors of cellular efflux pumps of microbes

Details Inhibitors of cellular efflux pumps of microbes Inhibitors of cellular efflux pumps of microbes

2006-08-29

2006-08-29

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S294000, C514S300000, C514S311000, C514S314000, C546S081000, C546S095000, C546S096000, C546S122000, C546S156000

Reexamination Certificate

active

07098219

ABSTRACT:
Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.

REFERENCES:
patent: 3924042 (1975-12-01), Gerster et al.
patent: 3984403 (1976-10-01), Fujisawa et al.
patent: 3985882 (1976-10-01), Gerster
patent: 4051247 (1977-09-01), Schuppan et al.
patent: 4382892 (1983-05-01), Hayakawa et al.
patent: 4399134 (1983-08-01), Ishikawa et al.
patent: 4404207 (1983-09-01), Stern
patent: 4416884 (1983-11-01), Ishikawa et al.
patent: 4443447 (1984-04-01), Gerster et al.
patent: 4472406 (1984-09-01), Gerster
patent: 4472407 (1984-09-01), Stern
patent: 4535161 (1985-08-01), Hayakawa
patent: 4552879 (1985-11-01), Ishikawa et al.
patent: 4563459 (1986-01-01), Grohe et al.
patent: 4594347 (1986-06-01), Ishikawa et al.
patent: 4599418 (1986-07-01), Irikura et al.
patent: 4638067 (1987-01-01), Culbertson et al.
patent: 4642355 (1987-02-01), Nakamura et al.
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4777175 (1988-10-01), Culbertson et al.
patent: 4822801 (1989-04-01), Domagala et al.
patent: 4874764 (1989-10-01), Ueda et al.
patent: 4894458 (1990-01-01), Masuzawa et al.
patent: 4935420 (1990-06-01), Ueda et al.
patent: 5051509 (1991-09-01), Nagano et al.
patent: 5097032 (1992-03-01), Domagala et al.
patent: 5185337 (1993-02-01), Fujii et al.
patent: 5607942 (1997-03-01), Petersen et al.
patent: 5639886 (1997-06-01), Zerbes et al.
patent: 5677316 (1997-10-01), Ao et al.
patent: 5859026 (1999-01-01), Ito
patent: 5869661 (1999-02-01), Ochi et al.
patent: 5889009 (1999-03-01), Miyake
patent: 5989832 (1999-11-01), Trias et al.
patent: 6034100 (2000-03-01), Adachi et al.
patent: 6121285 (2000-09-01), Takemura
patent: 6184388 (2001-02-01), Takemura
patent: 6329391 (2001-12-01), Ledoussal
patent: 1097751 (1995-01-01), None
patent: 0230295 (1987-07-01), None
patent: 0241206 (1987-10-01), None
patent: 0287951 (1988-10-01), None
patent: 0300735 (1989-01-01), None
patent: 0304087 (1989-02-01), None
patent: 0342675 (1989-11-01), None
patent: 0394553 (1990-10-01), None
patent: 0541086 (1993-05-01), None
patent: 0572259 (1993-12-01), None
patent: 0908181 (1999-04-01), None
patent: 0919553 (1999-06-01), None
patent: 57081486 (1982-05-01), None
patent: 57176987 (1982-10-01), None
patent: 58090511 (1983-05-01), None
patent: 63192753 (1988-08-01), None
patent: 02131483 (1990-05-01), None
patent: 02188570 (1990-07-01), None
patent: 02188589 (1990-07-01), None
patent: 05339238 (1993-12-01), None
patent: 9420105 (1994-09-01), None
patent: 9724128 (1997-07-01), None
patent: 9731000 (1997-08-01), None
patent: 9744034 (1997-11-01), None
patent: 9914214 (1999-03-01), None
patent: 9926940 (1999-06-01), None
patent: 0018404 (2000-04-01), None
patent: 0068229 (2000-11-01), None
patent: 0185095 (2001-11-01), None
patent: 0185728 (2001-11-01), None
patent: 0209758 (2002-02-01), None
patent: 8502369 (1985-12-01), None
Kurokawa, J of the American Academy of Dermatology, vol. 25(4), oo 674-681, Oct. 1991.
Haustein, J. of Dermatological Treatment, vol. 8, pp. 87-92, 1997.
Oizumi, N., et al. “Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin . . .Staphylococcus aureus” J. Infect Chemotherapy, vol. 7, p. 191-194, (2001).
Haustein, U-F., et al. “Topical quinolone nadifloxacin (OPC-7251) in bacterial skin disease: clinical evaluation . . . testing” J. of Dermatological Treatment , vol. 8, p. 87-92, (1997).
Kurokawa, J of the American Academy of Dermatology, 25(4), pp. 674-681, Oct. 1991.
Mergler et al. Proceedings of the 12thAmerican Peptide Symposium. Reference cited on p. 2 of EPA 0953577.
Alsina, et al.Tetrahedon Letters, v38 n5, (1997) 883-886.
Edwards et al.J. Med. Chem., v37 n22 (1994) 3749-3757.
A.M. Dhople, M.A. Tbanez: “In vivo susceptibility of mycobacterium leprae to ofloxacin either singly or in combination with rifampicin and rifabutin” Arzeimittel-Forschung, vol. 44, No. 4, 1994, pp. 563-565.
Haustein et al.J. of Dermatological Treatment, v8 (1997) 87-92.
Bundgaard, H.Design of Prodrugs. (1985) pp. 1-3.
Hashimoto et al.Chem. Pharm. Bull. V44, n4 (1996) pp. 642-645.
Irish, D. et al.J. of Hospital Infection, v39 (1998) pp. 19-26.
Kido, M. et al.Chem. Pharm. Bull. V42, n4 (1994) pp. 872-876.
Sloan et al.Physics and Chemistry of the Organic Solid State, eds. D. Fox, Labes and Weissberer, Interscience Publishers, (1963) 179-182.
Takahashi et al.Arzheim-Forsc/Drug Res., 45(1), Nr. 2 (1995), 199-197.
Morita, S. et al.Tetrahedoni: Assymetry, v6, n1 (1995) pp. 245-254.
Morita, S. et al.Chem. Pharm. Bull., 38(7) (1990) 2027-2029.
Ishikawa et al.Chem. Pharm. Bull., 37(8) (1989) 2103-2108.
English translation of Yamada, H. et al.Iyahukin Kenkyu, v31, n8 (2000) pp. 519-524.
English translation of Yamada, H. et al.Iyahukin Kenkyu, v31, n8 (2000) pp. 525-528.
Berge et al.J. of Pharmaceutical Sciences, 66(1) (1977) 1-19.
Abstract of Koike, M. et al.Iakuhin Kenkyu, v21, n5 (1990) pp. 998-1021.
Abstract of Koike, M. et al.Iyakuhim Kenkyu, v21, n5 (1990) pp. 1022-1033.
Abstract of Fujita, S. et al.Iyakuhin Kenkyu, v21, n6 (1990) pp. 1156-1176.
Abstract of Koike, M. et al.Yakubutsu Dotai, v5, n2 (1990) pp. 199-208.
Abstract of Yasuo, A.. et al.Yakuri to Chiryo, v18, n4 (1990) pp. 1717-1730.
Abstract of Hayakawa, R. et al.Hifu, v32, n2 (1990) pp. 217-230.
Abstract of Asada, Y. et al.Yakuri to Chiryo, v18, n4 (1990) pp. 1717-1730.
Abstract of Awogi, T. et al.Iyakuhin Kenkyu, v21, n4 (1990) pp. 626-635.
Abstract of Matsuzawa, A. et al.Iyakuhin Kenkyu, v21, n4 (1990) pp. 636-646.
Abstract of Nagao T. et al.Iyakuhin Kenkyu, v21, n4 (1990) pp. 647-662.
Abstract of Matsuzawa, A. et al.Iyakuhin Kenkyu, v21, n4 (1990) pp. 633-670.
Abstract of Hashimoto, K.. et al.Iyakuhin Kenkyu, v21, n4 (1990) pp. 670-677.
Abstract of Furukawa, M. et al.Iyakuhin Kenkyu, v21, n5 (1990) pp. 989-997.
Abstract of Kojima, K. et al.Iyakuhin Kenkyu, v21, n5 (1990) pp. 1034-1052.
Abstract of Nakagiri, N. et al.Iyakuhin Kenkyu, v21, n6 (1990) pp. 1144-1155.
Abstract of Aoki, M. et al.Iyakuhin Kenkyu, v21, n6 (1990) pp. 1177-1202.
Abstract of Matsuzawa, A. et al.Iyakuhin Kenkyu, v22, n1 (1990) pp. 61-76.
Abstract of Kurokawa I. et al.J. Am. Acad. Dermatol., v25, n4 (1991) pp. 674-681.
Abstract of Bojar, R. et al.J. of Investigative Dermatology, v103, n3 (1994) pp. 405.
E.M. Mateu-de-Antonio, M. Martin: “In vitro efficacy of several antimicrobial combinations againstBrucella canisandBrucella melitensisstrains isolated from dogs” Vet. Microbiology, vol. 45, No. 1, 1995, pp. 1-10.
Abstract of Smith, C.M. et al.J. of Investigative Dermatology, v108, n3 (1997) p. 123.
Abstract of Hayakawa, R. et al.Hifu, v40, n2 (1998) pp. 165-171.
Fujio, N. et al.Yakuri to Chiryo, v26, n7 (1998) pp. 1119-1132.
Kido, M. et al.Chem. Pharm. Bull., v44, n2 (1996) pp. 421-423.
Miller, M.A. et al.Infection Control and Hospital Epidemiology, v17, n12 (1995) pp. 811-813.
Nishijima, S. et al.The Journal of Int'l Medical Research, v23, (1995) pp. 328-334.
Nishijima, S. et al.Journal of Dermatology, v22, (1995) pp. 153-155.
Nishijima, S. et al.The Journal of Int'l Medical Research, v24, (1996) pp. 12-16.
Nishijima, S. et al.Journal of Dermatology, v21, (1994) pp. 233-238.
Udo, E. E. et al.J. of Hospital Infection, v26, (1994) pp. 157-165.
Abstract of Kurokawa, I. et al.European J. of Dermatolgoy, v9, n1 (1999) pp. 25-28.
Abstract of Komagata. et al.Japanese Journal of Antibiotics, v51, n2 (1998) pp. 130-136.
Abstract of Gollnick, H. et al.Dermatology, v196, n1(1998) pp. 119-125.
Abstract of Nishijima, S. et al.J. of Int'l Medical Research, v25, n4 (1997) pp. 210-213.
Abstract of Nishijima, S. et al.J. of In'tl Medical Research, v24, n6 (1996) pp. 473-477.
Abstract of Akamatsu, H. et al.J. of Int'l Medical Research, v23, n1 (1995) pp. 19-26.
Abstract of Takahashi, N. et al.Arzneimittel-Forschung, v45, n2 (1995) p. 195.
Abstract of Takahashi, N. et al.Arzneimittal-Forschung, v44, n11 (1994)

Affiliated with

Also associated with

Rating

Inhibitors of cellular efflux pumps of microbes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of cellular efflux pumps of microbes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of cellular efflux pumps of microbes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3656202