Inhibitors of cell-mediated disorders

Details Inhibitors of cell-mediated disorders Inhibitors of cell-mediated disorders

1997-06-11

1998-10-13

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514566, A61K 31555

Patent

active

058212655

ABSTRACT:
The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.

REFERENCES:
patent: 4529593 (1985-07-01), Warrell et al.
patent: 4704277 (1987-11-01), Bockman et al.
patent: 5196412 (1993-03-01), Bradley et al.

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