Inhibitors of cathepsin S

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S124000, C544S135000, C544S137000, C544S162000, C544S165000, C514S235800, C514S237800

Reexamination Certificate

active

10922515

ABSTRACT:
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula I:wherein Q is morpholinyl; andA, R5, R6, R7, R8, R9and Ar are substituents.

REFERENCES:
patent: 5932737 (1999-08-01), Itoh et al.
patent: 6313117 (2001-11-01), Bekkali et al.
patent: 6504014 (2003-01-01), Isaacs et al.
patent: 2004-256525 (2004-09-01), None
patent: WO 07/09110 (2001-02-01), None
patent: WO 01/81613 (2001-11-01), None

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