Inhibitors of cathepsin S

Details Inhibitors of cathepsin S Inhibitors of cathepsin S

2007-08-14

2007-08-14

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S387000, C548S304400, C548S306100

Reexamination Certificate

active

10922362

ABSTRACT:
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

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Bania, J. et al.: “Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs” PNAS; vol. 100, No. 11; pp. 6664-6669 (May 27, 2003).

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