Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-09-19
2006-09-19
O'Sullivan, Peter (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S237500, C514S249000, C514S275000, C514S279000, C514S255010, C514S330000, C514S355000, C514S364000, C514S359000, C514S406000, C514S394000, C514S422000, C514S416000, C514S448000, C514S459000, C514S471000, C514S472000, C514S602000, C514S603000, C514S604000, C514S522000, C514S596000, C514S598000, C544S165000, C544S231000, C544S332000, C544S312000, C544S391000, C546S226000, C546S316000, C548S131000, C548S255000, C548S269400, C548S304400, C548S374100, C548S492000, C548S517000, C548S560000
Reexamination Certificate
active
07109243
ABSTRACT:
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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Bania, J. et al.: “Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs” PNAS; vol. 100, No. 11; pp. 6664-6669 (May 27, 2003).
Bursulaya Badry
Chatterjee Arnab
Epple Robert
Harris Jennifer Leslie
Li Jun
IRM LLC
O'Sullivan Peter
Townsend and Townsend / and Crew LLP
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