Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-05
1996-04-23
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530323, 530328, 530329, 530330, 435218, 435219, 514 2, 514 16, 514 17, A61K 3807, A61K 3808
Patent
active
055103332
ABSTRACT:
Novel compounds which are chemically linked inhibitors of the proteases Elastase and Cathepsin G prevent connective tissue degradation associated with neutrophil induced inflammatory disease.
REFERENCES:
patent: 4485100 (1984-11-01), Hochstrasser et al.
patent: 4629724 (1986-12-01), Ryono et al.
patent: 4636489 (1987-01-01), Seemuller et al.
patent: 4643991 (1987-02-01), Digenis et al.
patent: 4873221 (1989-10-01), Trainor
patent: 4880780 (1989-11-01), Tranor et al.
patent: 4910190 (1990-03-01), Bergeson et al.
patent: 5055450 (1991-10-01), Edwards et al.
patent: 5061691 (1991-10-01), Yagi et al.
Powers et al; Pulmonary Emphysema and Proteolysis pp. 41-48 (1986).
Hornebeck et al; Cell Biochemistry and Function 5:113-122 (1987).
Johnson et al; J. Biol. Chem. 253(20):7142-4 (1978).
Nakajima et al; J. Biol. Chem. 254(10):4027-32 (1979).
Martodam et al; PNAS (USA) 76(5):2128-32 (1979).
McRae et al; Biochemistry 19:3973-8 (1980).
Reilly et al; Biochim. Biophys. Acta 621:147-57 (1980).
Ponpipom et al; J. Med. Chem. 24:1388-95 (1981).
The Merck Manual; 15th Ed. Berkow et al; Eds. pp. 620-623; 636-643 (1987).
Hornebeck et al; Chemical Abstracts 107:196313z (1987).
Poners et al; Chemical Abstracts 108:33954r (1988).
Drinkwater et al; J. Biol. Chem. 263(18):8565-68 (1988).
McWherter et al; Biochem. 28:5708-14 (1989).
Baba et al; J. Biol. Chem. 264(20):11920-7 (1989).
Rao et al; J. Biol. Chem. 266(15):9540-8 (1991, May 1975).
Tsubol et al; Chemical Abstracts 115:44919d (Aug. 5, 1991).
Steinmeyer et al; Arzneim.-Forsch./Drug Res. 41 I!, 1:77-80 (1991).
Hassall et al, Febs Lett, 183, 201-205, (1985).
Fletcher et al, Am. Rev. Respir. Dis., 141, 672-677, (1990).
Malech et al, New Engl. J. Med., 317, 687-694 (1987).
Snider, Eur. J. Respir. Dis., 69, (Suppl 146) 17-35, (1986).
Shah et al, J. Med. Chem., 35, 3745-3754, (1992).
Peet, et al, J. Med. Chem., 33, 394-407, (1990).
Angelastro et al, Bioorg. Med. Chem. Lett, 3, 525-530, (1990).
Mehdi, Bioorg. Chem., 21, 249-259, (1993).
Mehdi, S. et al., Biochemical and Biophysical Research Communications, vol. 166, No. 2, pp. 595-600 (1990).
Rice, W. G. et al., Science, vol. 249, pp. 178-181 (1990).
Angelastro Michael R.
Bey Philippe
Doherty Niall S.
Janusz Michael J.
Mehdi Shujaath
Boudreaux William R.
Fonda Kathleen Kahler
Merrell Pharmaceuticals Inc.
Robinson Douglas W.
LandOfFree
Inhibitors of Cathepsin G and elastase for preventing connective does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of Cathepsin G and elastase for preventing connective, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of Cathepsin G and elastase for preventing connective will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2308523